T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy

Memory T cells play an essential role in infectious and tumor immunity. Vitamin A metabolites such as retinoic acid are immune modulators, but the role of vitamin A metabolism in memory T-cell differentiation is unclear. In this study, we identified retinol dehydrogenase 10 (Rdh10), which metabolize...

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Detalles Bibliográficos
Autores principales: Fujiki, Fumihiro, Morimoto, Soyoko, Katsuhara, Akiko, Okuda, Akane, Ogawa, Saeka, Ueda, Eriko, Miyazaki, Maki, Isotani, Ayako, Ikawa, Masahito, Nishida, Sumiyuki, Nakajima, Hiroko, Tsuboi, Akihiro, Oka, Yoshihiro, Nakata, Jun, Hosen, Naoki, Kumanogoh, Atsushi, Oji, Yusuke, Sugiyama, Haruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280205/
https://www.ncbi.nlm.nih.gov/pubmed/35844620
http://dx.doi.org/10.3389/fimmu.2022.935465

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