Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines

An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/...

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Detalles Bibliográficos
Autores principales: Zhou, Zitong, Luo, Danyang, Li, Guanrong, Yang, Zhongtao, Cui, Liao, Yang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280286/
https://www.ncbi.nlm.nih.gov/pubmed/35919587
http://dx.doi.org/10.1039/d2ra02722d
Descripción
Sumario:An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/ring-cleavage process and forms a highly active intermediate α-acyl-N-sulfonyl ketenimine with base free.

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