Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines

An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/...

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Detalles Bibliográficos
Autores principales: Zhou, Zitong, Luo, Danyang, Li, Guanrong, Yang, Zhongtao, Cui, Liao, Yang, Weiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280286/
https://www.ncbi.nlm.nih.gov/pubmed/35919587
http://dx.doi.org/10.1039/d2ra02722d
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author Zhou, Zitong
Luo, Danyang
Li, Guanrong
Yang, Zhongtao
Cui, Liao
Yang, Weiguang
author_facet Zhou, Zitong
Luo, Danyang
Li, Guanrong
Yang, Zhongtao
Cui, Liao
Yang, Weiguang
author_sort Zhou, Zitong
collection PubMed
description An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/ring-cleavage process and forms a highly active intermediate α-acyl-N-sulfonyl ketenimine with base free.
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spelling pubmed-92802862022-08-01 Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines Zhou, Zitong Luo, Danyang Li, Guanrong Yang, Zhongtao Cui, Liao Yang, Weiguang RSC Adv Chemistry An efficient three-component one-pot and operationally simple cascade of 2-aminopyridines with sulfonyl azides and terminal ynones is reported, providing a variety of polysubstituted imidazo[1,2-a]pyridine derivatives in moderate to excellent yields. In particular, the reaction goes a through CuAAC/ring-cleavage process and forms a highly active intermediate α-acyl-N-sulfonyl ketenimine with base free. The Royal Society of Chemistry 2022-07-14 /pmc/articles/PMC9280286/ /pubmed/35919587 http://dx.doi.org/10.1039/d2ra02722d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhou, Zitong
Luo, Danyang
Li, Guanrong
Yang, Zhongtao
Cui, Liao
Yang, Weiguang
Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title_full Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title_fullStr Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title_full_unstemmed Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title_short Copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
title_sort copper-catalyzed three-component reaction to synthesize polysubstituted imidazo[1,2-a]pyridines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280286/
https://www.ncbi.nlm.nih.gov/pubmed/35919587
http://dx.doi.org/10.1039/d2ra02722d
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