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Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature
Primary CNS involvement is very rare in Hodgkin lymphoma. Here we present two cases of spinal cord dissemination. Two women of 40 and 65 years of age presented symptoms of spinal cord injury; imaging showed an intramedullary mass in T10 and T2, respectively, without vertebral involvement and upper d...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280417/ https://www.ncbi.nlm.nih.gov/pubmed/35694977 http://dx.doi.org/10.2217/cns-2021-0011 |
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author | Le Dû, Katell Alarion, Nicolas Rabi, Hassan Casasnovas, Olivier Robert, Philippine Durand, Amandine Burlet, Bénédicte Tabouret-Viaud, Claire Ramla, Selim Martin, Laurent Rossi, Cédric |
author_facet | Le Dû, Katell Alarion, Nicolas Rabi, Hassan Casasnovas, Olivier Robert, Philippine Durand, Amandine Burlet, Bénédicte Tabouret-Viaud, Claire Ramla, Selim Martin, Laurent Rossi, Cédric |
author_sort | Le Dû, Katell |
collection | PubMed |
description | Primary CNS involvement is very rare in Hodgkin lymphoma. Here we present two cases of spinal cord dissemination. Two women of 40 and 65 years of age presented symptoms of spinal cord injury; imaging showed an intramedullary mass in T10 and T2, respectively, without vertebral involvement and upper diaphragmatic lymph nodes. Lymph-node biopsy confirmed the diagnosis of classical Hodgkin lymphoma in both patients. The first patient received four cycles of chemotherapy (escalated BEACOPP and ABVD) with intrathecal therapy, and the second four cycles of doxorubicin, vinblastine, dacarbazine (AVD) and local irradiation after surgery decompression. Complete metabolic response was obtained at the end of treatment. After 5 and 7 years of follow-up respectively, neurological deficits persisted in both. |
format | Online Article Text |
id | pubmed-9280417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-92804172022-07-15 Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature Le Dû, Katell Alarion, Nicolas Rabi, Hassan Casasnovas, Olivier Robert, Philippine Durand, Amandine Burlet, Bénédicte Tabouret-Viaud, Claire Ramla, Selim Martin, Laurent Rossi, Cédric CNS Oncol Case Report Primary CNS involvement is very rare in Hodgkin lymphoma. Here we present two cases of spinal cord dissemination. Two women of 40 and 65 years of age presented symptoms of spinal cord injury; imaging showed an intramedullary mass in T10 and T2, respectively, without vertebral involvement and upper diaphragmatic lymph nodes. Lymph-node biopsy confirmed the diagnosis of classical Hodgkin lymphoma in both patients. The first patient received four cycles of chemotherapy (escalated BEACOPP and ABVD) with intrathecal therapy, and the second four cycles of doxorubicin, vinblastine, dacarbazine (AVD) and local irradiation after surgery decompression. Complete metabolic response was obtained at the end of treatment. After 5 and 7 years of follow-up respectively, neurological deficits persisted in both. Future Medicine Ltd 2022-06-13 /pmc/articles/PMC9280417/ /pubmed/35694977 http://dx.doi.org/10.2217/cns-2021-0011 Text en © 2022 Katell Le Du https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Report Le Dû, Katell Alarion, Nicolas Rabi, Hassan Casasnovas, Olivier Robert, Philippine Durand, Amandine Burlet, Bénédicte Tabouret-Viaud, Claire Ramla, Selim Martin, Laurent Rossi, Cédric Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title | Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title_full | Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title_fullStr | Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title_full_unstemmed | Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title_short | Extranodal classical Hodgkin lymphoma involving the spinal cord: case report and review of the literature |
title_sort | extranodal classical hodgkin lymphoma involving the spinal cord: case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280417/ https://www.ncbi.nlm.nih.gov/pubmed/35694977 http://dx.doi.org/10.2217/cns-2021-0011 |
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