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The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa : A large tertiary care university hospital experience in Riyadh, Saudi Arabia
OBJECTIVES: To assess the antibacterial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) from various body specimen types and different patterns of resistance. METHODS: A retrospective cohort study with a total of 49 MRSA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280555/ https://www.ncbi.nlm.nih.gov/pubmed/35022281 http://dx.doi.org/10.15537/smj.2022.43.1.20210587 |
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author | Altamimi, Lamees A. Altamimi, Leen A. Somily, Ali M. |
author_facet | Altamimi, Lamees A. Altamimi, Leen A. Somily, Ali M. |
author_sort | Altamimi, Lamees A. |
collection | PubMed |
description | OBJECTIVES: To assess the antibacterial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) from various body specimen types and different patterns of resistance. METHODS: A retrospective cohort study with a total of 49 MRSA and 99 P. aeruginosa isolated in the Microbiology Laboratory at King Saud University Medical City, Riyadh, Saudi Arabia, between 2018-2019, were used. Isolates were randomly selected from various specimen types. The minimum inhibition concentration (MIC) of ceftobiprole was determined by E-test. Breakpoints carried out by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) were used to assess antibiotic susceptibility. RESULTS: Approximately 100% of the MRSA isolates were susceptible with MIC50/90 value of 1/1.5 mg/L while 69.8% of multi-drug resistant (MDR) P. aeruginosa isolates were resistant with MIC50/90 value of 16/32 mg/L. CONCLUSION: The excellent activity of ceftobiprole against MRSA would have major implications in management of the patients with serious infections, as an empirical treatment or alternative to vancomycin. Ceftobiprole has a very low activity against MDR P. aeruginosa, and its susceptibility should be tested prior to use for treatment. |
format | Online Article Text |
id | pubmed-9280555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-92805552022-07-20 The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa : A large tertiary care university hospital experience in Riyadh, Saudi Arabia Altamimi, Lamees A. Altamimi, Leen A. Somily, Ali M. Saudi Med J Original Articles OBJECTIVES: To assess the antibacterial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa) from various body specimen types and different patterns of resistance. METHODS: A retrospective cohort study with a total of 49 MRSA and 99 P. aeruginosa isolated in the Microbiology Laboratory at King Saud University Medical City, Riyadh, Saudi Arabia, between 2018-2019, were used. Isolates were randomly selected from various specimen types. The minimum inhibition concentration (MIC) of ceftobiprole was determined by E-test. Breakpoints carried out by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) were used to assess antibiotic susceptibility. RESULTS: Approximately 100% of the MRSA isolates were susceptible with MIC50/90 value of 1/1.5 mg/L while 69.8% of multi-drug resistant (MDR) P. aeruginosa isolates were resistant with MIC50/90 value of 16/32 mg/L. CONCLUSION: The excellent activity of ceftobiprole against MRSA would have major implications in management of the patients with serious infections, as an empirical treatment or alternative to vancomycin. Ceftobiprole has a very low activity against MDR P. aeruginosa, and its susceptibility should be tested prior to use for treatment. Saudi Medical Journal 2022-01 /pmc/articles/PMC9280555/ /pubmed/35022281 http://dx.doi.org/10.15537/smj.2022.43.1.20210587 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. |
spellingShingle | Original Articles Altamimi, Lamees A. Altamimi, Leen A. Somily, Ali M. The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa : A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title | The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa
: A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title_full | The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa
: A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title_fullStr | The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa
: A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title_full_unstemmed | The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa
: A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title_short | The antimicrobial activity of ceftobiprole against Methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa
: A large tertiary care university hospital experience in Riyadh, Saudi Arabia |
title_sort | antimicrobial activity of ceftobiprole against methicillin-resistant staphylococcus aureus and multi-drug resistant pseudomonas aeruginosa
: a large tertiary care university hospital experience in riyadh, saudi arabia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280555/ https://www.ncbi.nlm.nih.gov/pubmed/35022281 http://dx.doi.org/10.15537/smj.2022.43.1.20210587 |
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