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Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280589/ https://www.ncbi.nlm.nih.gov/pubmed/35537723 http://dx.doi.org/10.15537/smj.2022.43.5.20220045 |
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author | Alqahtani, Saad M. Alanesi, Sultan F. Mahmood, Waqas S. Moustafa, Yassin M. Moharram, Laila M. Alharthi, Nawaf F. Alzahrani, Attiya M. Alalawi, Yousef S. |
author_facet | Alqahtani, Saad M. Alanesi, Sultan F. Mahmood, Waqas S. Moustafa, Yassin M. Moharram, Laila M. Alharthi, Nawaf F. Alzahrani, Attiya M. Alalawi, Yousef S. |
author_sort | Alqahtani, Saad M. |
collection | PubMed |
description | OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017). RESULTS: Forty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy. CONCLUSION: None of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules. |
format | Online Article Text |
id | pubmed-9280589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-92805892022-07-22 Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules Alqahtani, Saad M. Alanesi, Sultan F. Mahmood, Waqas S. Moustafa, Yassin M. Moharram, Laila M. Alharthi, Nawaf F. Alzahrani, Attiya M. Alalawi, Yousef S. Saudi Med J Original Article OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017). RESULTS: Forty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy. CONCLUSION: None of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules. Saudi Medical Journal 2022-05 /pmc/articles/PMC9280589/ /pubmed/35537723 http://dx.doi.org/10.15537/smj.2022.43.5.20220045 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. |
spellingShingle | Original Article Alqahtani, Saad M. Alanesi, Sultan F. Mahmood, Waqas S. Moustafa, Yassin M. Moharram, Laila M. Alharthi, Nawaf F. Alzahrani, Attiya M. Alalawi, Yousef S. Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title | Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title_full | Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title_fullStr | Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title_full_unstemmed | Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title_short | Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
title_sort | clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280589/ https://www.ncbi.nlm.nih.gov/pubmed/35537723 http://dx.doi.org/10.15537/smj.2022.43.5.20220045 |
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