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Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules

OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypi...

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Autores principales: Alqahtani, Saad M., Alanesi, Sultan F., Mahmood, Waqas S., Moustafa, Yassin M., Moharram, Laila M., Alharthi, Nawaf F., Alzahrani, Attiya M., Alalawi, Yousef S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280589/
https://www.ncbi.nlm.nih.gov/pubmed/35537723
http://dx.doi.org/10.15537/smj.2022.43.5.20220045
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author Alqahtani, Saad M.
Alanesi, Sultan F.
Mahmood, Waqas S.
Moustafa, Yassin M.
Moharram, Laila M.
Alharthi, Nawaf F.
Alzahrani, Attiya M.
Alalawi, Yousef S.
author_facet Alqahtani, Saad M.
Alanesi, Sultan F.
Mahmood, Waqas S.
Moustafa, Yassin M.
Moharram, Laila M.
Alharthi, Nawaf F.
Alzahrani, Attiya M.
Alalawi, Yousef S.
author_sort Alqahtani, Saad M.
collection PubMed
description OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017). RESULTS: Forty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy. CONCLUSION: None of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules.
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spelling pubmed-92805892022-07-22 Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules Alqahtani, Saad M. Alanesi, Sultan F. Mahmood, Waqas S. Moustafa, Yassin M. Moharram, Laila M. Alharthi, Nawaf F. Alzahrani, Attiya M. Alalawi, Yousef S. Saudi Med J Original Article OBJECTIVES: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy. METHODS: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017). RESULTS: Forty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy. CONCLUSION: None of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules. Saudi Medical Journal 2022-05 /pmc/articles/PMC9280589/ /pubmed/35537723 http://dx.doi.org/10.15537/smj.2022.43.5.20220045 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Alqahtani, Saad M.
Alanesi, Sultan F.
Mahmood, Waqas S.
Moustafa, Yassin M.
Moharram, Laila M.
Alharthi, Nawaf F.
Alzahrani, Attiya M.
Alalawi, Yousef S.
Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title_full Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title_fullStr Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title_full_unstemmed Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title_short Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
title_sort clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280589/
https://www.ncbi.nlm.nih.gov/pubmed/35537723
http://dx.doi.org/10.15537/smj.2022.43.5.20220045
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