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Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center
Hepatocellular carcinoma (HCC) represents the primary carcinoma of the liver and the fourth leading cause of cancer-related deaths. The World Health Organization estimates an increase in cases in the coming years. The risk factors of HCC are multiple, and the incidence in different countries is clos...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280731/ https://www.ncbi.nlm.nih.gov/pubmed/35978866 http://dx.doi.org/10.3748/wjg.v28.i25.2854 |
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author | Maloberti, Thais De Leo, Antonio Sanza, Viviana Gruppioni, Elisa Altimari, Annalisa Riefolo, Mattia Visani, Michela Malvi, Deborah D’Errico, Antonia Tallini, Giovanni Vasuri, Francesco de Biase, Dario |
author_facet | Maloberti, Thais De Leo, Antonio Sanza, Viviana Gruppioni, Elisa Altimari, Annalisa Riefolo, Mattia Visani, Michela Malvi, Deborah D’Errico, Antonia Tallini, Giovanni Vasuri, Francesco de Biase, Dario |
author_sort | Maloberti, Thais |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) represents the primary carcinoma of the liver and the fourth leading cause of cancer-related deaths. The World Health Organization estimates an increase in cases in the coming years. The risk factors of HCC are multiple, and the incidence in different countries is closely related to the different risk factors to which the population is exposed. The molecular mechanisms that drive HCC tumorigenesis are extremely complex, but understanding this multistep process is essential for the identification of diagnostic, prognostic, and therapeutic markers. The development of multigenic next-generation sequencing panels through the parallel analysis of multiple markers can provide a landscape of the genomic status of the tumor. Considering the literature and our preliminary data based on 36 HCCs, the most frequently altered genes in HCCs are TERT, CTNNB1, and TP53. Over the years, many groups have attempted to classify HCCs on a molecular basis, but a univocal classification has never been achieved. Nevertheless, statistically significant correlations have been found in HCCs between the molecular signature and morphologic features, and this leads us to think that it would be desirable to integrate the approach between anatomic pathology and molecular laboratories. |
format | Online Article Text |
id | pubmed-9280731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-92807312022-08-16 Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center Maloberti, Thais De Leo, Antonio Sanza, Viviana Gruppioni, Elisa Altimari, Annalisa Riefolo, Mattia Visani, Michela Malvi, Deborah D’Errico, Antonia Tallini, Giovanni Vasuri, Francesco de Biase, Dario World J Gastroenterol Minireviews Hepatocellular carcinoma (HCC) represents the primary carcinoma of the liver and the fourth leading cause of cancer-related deaths. The World Health Organization estimates an increase in cases in the coming years. The risk factors of HCC are multiple, and the incidence in different countries is closely related to the different risk factors to which the population is exposed. The molecular mechanisms that drive HCC tumorigenesis are extremely complex, but understanding this multistep process is essential for the identification of diagnostic, prognostic, and therapeutic markers. The development of multigenic next-generation sequencing panels through the parallel analysis of multiple markers can provide a landscape of the genomic status of the tumor. Considering the literature and our preliminary data based on 36 HCCs, the most frequently altered genes in HCCs are TERT, CTNNB1, and TP53. Over the years, many groups have attempted to classify HCCs on a molecular basis, but a univocal classification has never been achieved. Nevertheless, statistically significant correlations have been found in HCCs between the molecular signature and morphologic features, and this leads us to think that it would be desirable to integrate the approach between anatomic pathology and molecular laboratories. Baishideng Publishing Group Inc 2022-07-07 2022-07-07 /pmc/articles/PMC9280731/ /pubmed/35978866 http://dx.doi.org/10.3748/wjg.v28.i25.2854 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Maloberti, Thais De Leo, Antonio Sanza, Viviana Gruppioni, Elisa Altimari, Annalisa Riefolo, Mattia Visani, Michela Malvi, Deborah D’Errico, Antonia Tallini, Giovanni Vasuri, Francesco de Biase, Dario Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title | Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title_full | Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title_fullStr | Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title_full_unstemmed | Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title_short | Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center |
title_sort | correlation of molecular alterations with pathological features in hepatocellular carcinoma: literature review and experience of an italian center |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280731/ https://www.ncbi.nlm.nih.gov/pubmed/35978866 http://dx.doi.org/10.3748/wjg.v28.i25.2854 |
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