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Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

Patients with inflammatory bowel disease (IBD) are more likely to have concurrent immune-mediated inflammatory diseases (IMIDs) than those without IBD. IMIDs have been observed to alter the phenotype and outcomes of IBD in recent studies. Several studies have found that IBD patients with concurrent...

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Autores principales: Akiyama, Shintaro, Fukuda, Soma, Steinberg, Joshua M, Suzuki, Hideo, Tsuchiya, Kiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280738/
https://www.ncbi.nlm.nih.gov/pubmed/35978883
http://dx.doi.org/10.3748/wjg.v28.i25.2843
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author Akiyama, Shintaro
Fukuda, Soma
Steinberg, Joshua M
Suzuki, Hideo
Tsuchiya, Kiichiro
author_facet Akiyama, Shintaro
Fukuda, Soma
Steinberg, Joshua M
Suzuki, Hideo
Tsuchiya, Kiichiro
author_sort Akiyama, Shintaro
collection PubMed
description Patients with inflammatory bowel disease (IBD) are more likely to have concurrent immune-mediated inflammatory diseases (IMIDs) than those without IBD. IMIDs have been observed to alter the phenotype and outcomes of IBD in recent studies. Several studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes, and are considered to be at increased risk of requiring biologics and IBD-related surgeries, suggesting that having multiple IMIDs is a poor prognostic factor for IBD. Furthermore, IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes, suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory distributions. In this review, we discuss the pathogenesis, disease phenotypes, and clinical outcomes in IBD patients with concomitant IMIDs.
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spelling pubmed-92807382022-08-16 Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases Akiyama, Shintaro Fukuda, Soma Steinberg, Joshua M Suzuki, Hideo Tsuchiya, Kiichiro World J Gastroenterol Minireviews Patients with inflammatory bowel disease (IBD) are more likely to have concurrent immune-mediated inflammatory diseases (IMIDs) than those without IBD. IMIDs have been observed to alter the phenotype and outcomes of IBD in recent studies. Several studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes, and are considered to be at increased risk of requiring biologics and IBD-related surgeries, suggesting that having multiple IMIDs is a poor prognostic factor for IBD. Furthermore, IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes, suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory distributions. In this review, we discuss the pathogenesis, disease phenotypes, and clinical outcomes in IBD patients with concomitant IMIDs. Baishideng Publishing Group Inc 2022-07-07 2022-07-07 /pmc/articles/PMC9280738/ /pubmed/35978883 http://dx.doi.org/10.3748/wjg.v28.i25.2843 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/ -Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Akiyama, Shintaro
Fukuda, Soma
Steinberg, Joshua M
Suzuki, Hideo
Tsuchiya, Kiichiro
Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title_full Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title_fullStr Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title_full_unstemmed Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title_short Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
title_sort characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280738/
https://www.ncbi.nlm.nih.gov/pubmed/35978883
http://dx.doi.org/10.3748/wjg.v28.i25.2843
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