Investigation of the Captopril–Insulin Interaction by Mass Spectrometry and Computational Approaches Reveals that Captopril Induces Structural Changes in Insulin

[Image: see text] Post-translational modifications remarkably regulate proteins’ biological function. Small molecules such as reactive thiols, metabolites, and drugs may covalently modify the proteins and cause structural changes. This study reports the covalent modification and noncovalent interact...

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Autores principales: Ghosh, Amrita, Pawar, Aiswarya B., Chirmade, Tejas, Jathar, Swaraj M., Bhambure, Rahul, Sengupta, Durba, Giri, Ashok P., Kulkarni, Mahesh J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280767/
https://www.ncbi.nlm.nih.gov/pubmed/35847342
http://dx.doi.org/10.1021/acsomega.2c00660

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