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Primary cilia and ciliary signaling pathways in aging and age-related brain disorders

Brain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral...

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Autores principales: Ma, Rong, Kutchy, Naseer A., Chen, Liang, Meigs, Douglas D., Hu, Guoku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280856/
https://www.ncbi.nlm.nih.gov/pubmed/34979259
http://dx.doi.org/10.1016/j.nbd.2021.105607
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author Ma, Rong
Kutchy, Naseer A.
Chen, Liang
Meigs, Douglas D.
Hu, Guoku
author_facet Ma, Rong
Kutchy, Naseer A.
Chen, Liang
Meigs, Douglas D.
Hu, Guoku
author_sort Ma, Rong
collection PubMed
description Brain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases. Emerging studies suggest that primary cilia could be a key regulator in brain diseases. The primary cilium is a singular cellular organelle expressed on the surface of many cell types, such as astrocytes and neurons in the mature brain. Primary cilia detect extracellular cues, such as Sonic Hedgehog (SHH) protein, and transduce these signals into cells to regulate various signaling pathways. Abnormalities in ciliary length and frequency (ratio of ciliated cells) have been implicated in various human diseases, including brain disorders. This review summarizes current findings and thoughts on the role of primary cilia and ciliary signaling pathways in aging and age-related brain disorders.
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spelling pubmed-92808562022-07-14 Primary cilia and ciliary signaling pathways in aging and age-related brain disorders Ma, Rong Kutchy, Naseer A. Chen, Liang Meigs, Douglas D. Hu, Guoku Neurobiol Dis Article Brain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases. Emerging studies suggest that primary cilia could be a key regulator in brain diseases. The primary cilium is a singular cellular organelle expressed on the surface of many cell types, such as astrocytes and neurons in the mature brain. Primary cilia detect extracellular cues, such as Sonic Hedgehog (SHH) protein, and transduce these signals into cells to regulate various signaling pathways. Abnormalities in ciliary length and frequency (ratio of ciliated cells) have been implicated in various human diseases, including brain disorders. This review summarizes current findings and thoughts on the role of primary cilia and ciliary signaling pathways in aging and age-related brain disorders. 2022-02 2021-12-31 /pmc/articles/PMC9280856/ /pubmed/34979259 http://dx.doi.org/10.1016/j.nbd.2021.105607 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Ma, Rong
Kutchy, Naseer A.
Chen, Liang
Meigs, Douglas D.
Hu, Guoku
Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title_full Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title_fullStr Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title_full_unstemmed Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title_short Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
title_sort primary cilia and ciliary signaling pathways in aging and age-related brain disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280856/
https://www.ncbi.nlm.nih.gov/pubmed/34979259
http://dx.doi.org/10.1016/j.nbd.2021.105607
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