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Clival Paraganglioma, Case Report and Literature Review

Paragangliomas are rare tumors that may present with cranial neuropathies when located along the skull base. Supratentorial paragangliomas are less likely to secrete catecholamines but should be worked up, nonetheless. We highlight a case of a female in her fourth decade found to have a petroclival...

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Autores principales: Moor, Rachel, Goutnik, Michael, Lucke-Wold, Brandon, Laurent, Dimitri, Chen, Si, Friedman, William, Rahman, Maryam, Allen, Nichole, Rivera-Zengotita, Marie, Koch, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280865/
https://www.ncbi.nlm.nih.gov/pubmed/35844205
http://dx.doi.org/10.21926/obm.neurobiol.2203128
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author Moor, Rachel
Goutnik, Michael
Lucke-Wold, Brandon
Laurent, Dimitri
Chen, Si
Friedman, William
Rahman, Maryam
Allen, Nichole
Rivera-Zengotita, Marie
Koch, Matthew
author_facet Moor, Rachel
Goutnik, Michael
Lucke-Wold, Brandon
Laurent, Dimitri
Chen, Si
Friedman, William
Rahman, Maryam
Allen, Nichole
Rivera-Zengotita, Marie
Koch, Matthew
author_sort Moor, Rachel
collection PubMed
description Paragangliomas are rare tumors that may present with cranial neuropathies when located along the skull base. Supratentorial paragangliomas are less likely to secrete catecholamines but should be worked up, nonetheless. We highlight a case of a female in her fourth decade found to have a petroclival lesion following initial presentation that included one month of tooth pain, dysphagia, diplopia, hoarseness and right hemifacial hypoesthesia. Magnetic resonance imaging of the brain demonstrated a T2 hyperintense lesion favored to be a petroclival meningioma. Pre-operative angiography demonstrated a hypervascular tumor. She underwent a combined presigmoid craniotomy with posterior petrosectomy performed by both neurosurgery and neuro-otology. Pathology demonstrated paraganglioma. She had small volume residual tumor and is planned for continued outpatient radiotherapy. Paragangliomas should be on the differential for skull base lesions. Management paradigm involves multidisciplinary care and a combination of surgical resection and post-operative radiation. In this paper, we discuss underlying pathophysiology as well as appropriate workup and management.
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spelling pubmed-92808652022-07-14 Clival Paraganglioma, Case Report and Literature Review Moor, Rachel Goutnik, Michael Lucke-Wold, Brandon Laurent, Dimitri Chen, Si Friedman, William Rahman, Maryam Allen, Nichole Rivera-Zengotita, Marie Koch, Matthew OBM Neurobiol Article Paragangliomas are rare tumors that may present with cranial neuropathies when located along the skull base. Supratentorial paragangliomas are less likely to secrete catecholamines but should be worked up, nonetheless. We highlight a case of a female in her fourth decade found to have a petroclival lesion following initial presentation that included one month of tooth pain, dysphagia, diplopia, hoarseness and right hemifacial hypoesthesia. Magnetic resonance imaging of the brain demonstrated a T2 hyperintense lesion favored to be a petroclival meningioma. Pre-operative angiography demonstrated a hypervascular tumor. She underwent a combined presigmoid craniotomy with posterior petrosectomy performed by both neurosurgery and neuro-otology. Pathology demonstrated paraganglioma. She had small volume residual tumor and is planned for continued outpatient radiotherapy. Paragangliomas should be on the differential for skull base lesions. Management paradigm involves multidisciplinary care and a combination of surgical resection and post-operative radiation. In this paper, we discuss underlying pathophysiology as well as appropriate workup and management. 2022 2022-07-07 /pmc/articles/PMC9280865/ /pubmed/35844205 http://dx.doi.org/10.21926/obm.neurobiol.2203128 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the conditions of the Creative Commons by Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.
spellingShingle Article
Moor, Rachel
Goutnik, Michael
Lucke-Wold, Brandon
Laurent, Dimitri
Chen, Si
Friedman, William
Rahman, Maryam
Allen, Nichole
Rivera-Zengotita, Marie
Koch, Matthew
Clival Paraganglioma, Case Report and Literature Review
title Clival Paraganglioma, Case Report and Literature Review
title_full Clival Paraganglioma, Case Report and Literature Review
title_fullStr Clival Paraganglioma, Case Report and Literature Review
title_full_unstemmed Clival Paraganglioma, Case Report and Literature Review
title_short Clival Paraganglioma, Case Report and Literature Review
title_sort clival paraganglioma, case report and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9280865/
https://www.ncbi.nlm.nih.gov/pubmed/35844205
http://dx.doi.org/10.21926/obm.neurobiol.2203128
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