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Generation of genome-edited dogs by somatic cell nuclear transfer

BACKGROUND: Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease. RESULTS: We constructed a CRISPR-Cas9 vector targeting cani...

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Detalles Bibliográficos
Autores principales:	Kim, Dong-Ern, Lee, Ji-Hye, Ji, Kuk-Bin, Park, Kang-Sun, Kil, Tae-Young, Koo, Okjae, Kim, Min-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281017/ https://www.ncbi.nlm.nih.gov/pubmed/35831828 http://dx.doi.org/10.1186/s12896-022-00749-3

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