Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction

BACKGROUND: A pro-oxidant enzyme, NADPH oxidase 4 (Nox4) has been reported to be a critical downstream effector of TGFβ-induced myofibroblast transformation during fibrosis. While there are a small number of studies suggesting an oncogenic role of Nox4 derived from activated fibroblasts, direct evid...

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Detalles Bibliográficos
Autores principales: Mir, Shakeel, Golden, Briana D. Ormsbee, Griess, Brandon J., Vengoji, Raghupathy, Tom, Eric, Kosmacek, Elizabeth A., Oberley-Deegan, Rebecca E., Talmon, Geoffrey A., Band, Vimla, Teoh-Fitzgerald, Melissa LT.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281082/
https://www.ncbi.nlm.nih.gov/pubmed/35836253
http://dx.doi.org/10.1186/s13058-022-01548-6

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