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Does group-based trajectory modeling estimate spurious trajectories?

BACKGROUND: Group-based trajectory modelling (GBTM) is increasingly used to identify subgroups of individuals with similar patterns. In this paper, we use simulated and real-life data to illustrate that GBTM is susceptible to generating spurious findings in some circumstances. METHODS: Six plausible...

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Autores principales: Mésidor, Miceline, Rousseau, Marie-Claude, O’Loughlin, Jennifer, Sylvestre, Marie-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281109/
https://www.ncbi.nlm.nih.gov/pubmed/35836129
http://dx.doi.org/10.1186/s12874-022-01622-9
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author Mésidor, Miceline
Rousseau, Marie-Claude
O’Loughlin, Jennifer
Sylvestre, Marie-Pierre
author_facet Mésidor, Miceline
Rousseau, Marie-Claude
O’Loughlin, Jennifer
Sylvestre, Marie-Pierre
author_sort Mésidor, Miceline
collection PubMed
description BACKGROUND: Group-based trajectory modelling (GBTM) is increasingly used to identify subgroups of individuals with similar patterns. In this paper, we use simulated and real-life data to illustrate that GBTM is susceptible to generating spurious findings in some circumstances. METHODS: Six plausible scenarios, two of which mimicked published analyses, were simulated. Models with 1 to 10 trajectory subgroups were estimated and the model that minimized the Bayes criterion was selected. For each scenario, we assessed whether the method identified the correct number of trajectories, the correct shapes of the trajectories, and the mean number of participants of each trajectory subgroup. The performance of the average posterior probabilities, relative entropy and mismatch criteria to assess classification adequacy were compared. RESULTS: Among the six scenarios, the correct number of trajectories was identified in two, the correct shapes in four and the mean number of participants of each trajectory subgroup in only one. Relative entropy and mismatch outperformed the average posterior probability in detecting spurious trajectories. CONCLUSION: Researchers should be aware that GBTM can generate spurious findings, especially when the average posterior probability is used as the sole criterion to evaluate model fit. Several model adequacy criteria should be used to assess classification adequacy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12874-022-01622-9.
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spelling pubmed-92811092022-07-15 Does group-based trajectory modeling estimate spurious trajectories? Mésidor, Miceline Rousseau, Marie-Claude O’Loughlin, Jennifer Sylvestre, Marie-Pierre BMC Med Res Methodol Research BACKGROUND: Group-based trajectory modelling (GBTM) is increasingly used to identify subgroups of individuals with similar patterns. In this paper, we use simulated and real-life data to illustrate that GBTM is susceptible to generating spurious findings in some circumstances. METHODS: Six plausible scenarios, two of which mimicked published analyses, were simulated. Models with 1 to 10 trajectory subgroups were estimated and the model that minimized the Bayes criterion was selected. For each scenario, we assessed whether the method identified the correct number of trajectories, the correct shapes of the trajectories, and the mean number of participants of each trajectory subgroup. The performance of the average posterior probabilities, relative entropy and mismatch criteria to assess classification adequacy were compared. RESULTS: Among the six scenarios, the correct number of trajectories was identified in two, the correct shapes in four and the mean number of participants of each trajectory subgroup in only one. Relative entropy and mismatch outperformed the average posterior probability in detecting spurious trajectories. CONCLUSION: Researchers should be aware that GBTM can generate spurious findings, especially when the average posterior probability is used as the sole criterion to evaluate model fit. Several model adequacy criteria should be used to assess classification adequacy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12874-022-01622-9. BioMed Central 2022-07-14 /pmc/articles/PMC9281109/ /pubmed/35836129 http://dx.doi.org/10.1186/s12874-022-01622-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mésidor, Miceline
Rousseau, Marie-Claude
O’Loughlin, Jennifer
Sylvestre, Marie-Pierre
Does group-based trajectory modeling estimate spurious trajectories?
title Does group-based trajectory modeling estimate spurious trajectories?
title_full Does group-based trajectory modeling estimate spurious trajectories?
title_fullStr Does group-based trajectory modeling estimate spurious trajectories?
title_full_unstemmed Does group-based trajectory modeling estimate spurious trajectories?
title_short Does group-based trajectory modeling estimate spurious trajectories?
title_sort does group-based trajectory modeling estimate spurious trajectories?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281109/
https://www.ncbi.nlm.nih.gov/pubmed/35836129
http://dx.doi.org/10.1186/s12874-022-01622-9
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