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HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features

Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar ca...

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Autores principales: Guerrero, José, Trias, Isabel, Veloza, Luis, del Pino, Marta, Garcia, Adriana, Marimon, Lorena, Diaz-Mercedes, Sherley, Rodrigo-Calvo, Maria T., Alós, Silvia, Ajami, Tarek, Parra-Medina, Rafael, Martinez, Antonio, Reig, Oscar, Ribal, Maria J., Corral-Molina, Juan M., Ordi, Jaume, Ribera-Cortada, Inmaculada, Rakislova, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281510/
https://www.ncbi.nlm.nih.gov/pubmed/35297786
http://dx.doi.org/10.1097/PAS.0000000000001885
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author Guerrero, José
Trias, Isabel
Veloza, Luis
del Pino, Marta
Garcia, Adriana
Marimon, Lorena
Diaz-Mercedes, Sherley
Rodrigo-Calvo, Maria T.
Alós, Silvia
Ajami, Tarek
Parra-Medina, Rafael
Martinez, Antonio
Reig, Oscar
Ribal, Maria J.
Corral-Molina, Juan M.
Ordi, Jaume
Ribera-Cortada, Inmaculada
Rakislova, Natalia
author_facet Guerrero, José
Trias, Isabel
Veloza, Luis
del Pino, Marta
Garcia, Adriana
Marimon, Lorena
Diaz-Mercedes, Sherley
Rodrigo-Calvo, Maria T.
Alós, Silvia
Ajami, Tarek
Parra-Medina, Rafael
Martinez, Antonio
Reig, Oscar
Ribal, Maria J.
Corral-Molina, Juan M.
Ordi, Jaume
Ribera-Cortada, Inmaculada
Rakislova, Natalia
author_sort Guerrero, José
collection PubMed
description Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83 y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL.
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spelling pubmed-92815102022-08-02 HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features Guerrero, José Trias, Isabel Veloza, Luis del Pino, Marta Garcia, Adriana Marimon, Lorena Diaz-Mercedes, Sherley Rodrigo-Calvo, Maria T. Alós, Silvia Ajami, Tarek Parra-Medina, Rafael Martinez, Antonio Reig, Oscar Ribal, Maria J. Corral-Molina, Juan M. Ordi, Jaume Ribera-Cortada, Inmaculada Rakislova, Natalia Am J Surg Pathol Original Articles Most human papillomavirus (HPV)-independent penile squamous cell carcinomas (PSCCs) originate from an intraepithelial precursor called differentiated penile intraepithelial neoplasia, characterized by atypia limited to the basal layer with marked superficial maturation. Previous studies in vulvar cancer, which has a similar dual etiopathogenesis, have shown that about one fifth of HPV-independent precursors are morphologically indistinguishable from high-grade squamous intraepithelial lesions (HSILs), the precursor of HPV-asssociated carcinomas. However, such lesions have not been described in PSCC. From 2000 to 2021, 55 surgical specimens of PSCC were identified. In all cases, thorough morphologic evaluation, HPV DNA detection, and p16, p53, and Ki-67 immunohistochemical (IHC) staining was performed. HPV-independent status was assigned based on both negative results for p16 IHC and HPV DNA. Thirty-six of the 55 PSCC (65%) were HPV-independent. An intraepithelial precursor was identified in 26/36 cases (72%). Five of them (19%) had basaloid features, morphologically indistinguishable from HPV-associated HSIL. The median age of the 5 patients was 74 years (range: 67 to 83 y). All 5 cases were p16 and DNA HPV-negative. Immunohistochemically, 3 cases showed an abnormal p53 pattern, and 2 showed wild-type p53 staining. The associated invasive carcinoma was basaloid in 4 cases and the usual (keratinizing) type in 1. In conclusion, a small proportion of HPV-independent PSCC may arise on adjacent intraepithelial lesions morphologically identical to HPV-associated HSIL. This unusual histologic pattern has not been previously characterized in detail in PSCC. p16 IHC is a valuable tool to identify these lesions and differentiate them from HPV-associated HSIL. Lippincott Williams & Wilkins 2022-08 2022-03-17 /pmc/articles/PMC9281510/ /pubmed/35297786 http://dx.doi.org/10.1097/PAS.0000000000001885 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Articles
Guerrero, José
Trias, Isabel
Veloza, Luis
del Pino, Marta
Garcia, Adriana
Marimon, Lorena
Diaz-Mercedes, Sherley
Rodrigo-Calvo, Maria T.
Alós, Silvia
Ajami, Tarek
Parra-Medina, Rafael
Martinez, Antonio
Reig, Oscar
Ribal, Maria J.
Corral-Molina, Juan M.
Ordi, Jaume
Ribera-Cortada, Inmaculada
Rakislova, Natalia
HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title_full HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title_fullStr HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title_full_unstemmed HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title_short HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features
title_sort hpv-negative penile intraepithelial neoplasia (pein) with basaloid features
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281510/
https://www.ncbi.nlm.nih.gov/pubmed/35297786
http://dx.doi.org/10.1097/PAS.0000000000001885
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