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Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients
The aim of this study was to compare the relationship between shock index (SI) and respiratory adjusted shock index (RASI) scores with the final outcome of sepsis patients referred to the emergency department. This was prospective research that examined individuals who had been diagnosed with sepsis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281559/ https://www.ncbi.nlm.nih.gov/pubmed/35847795 http://dx.doi.org/10.3389/fmed.2022.872725 |
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author | Hashemian, Amir Masoud Baghshani, Zahra Farzaneh, Roohie Zamani Moghadam, Hamid Maleki, Fatemeh Bagherian, Farhad Ahmadnezhad, Somayyeh Foroughian, Mahdi |
author_facet | Hashemian, Amir Masoud Baghshani, Zahra Farzaneh, Roohie Zamani Moghadam, Hamid Maleki, Fatemeh Bagherian, Farhad Ahmadnezhad, Somayyeh Foroughian, Mahdi |
author_sort | Hashemian, Amir Masoud |
collection | PubMed |
description | The aim of this study was to compare the relationship between shock index (SI) and respiratory adjusted shock index (RASI) scores with the final outcome of sepsis patients referred to the emergency department. This was prospective research that examined individuals who had been diagnosed with sepsis, determined by the presence of at least two of the three quick sepsis-related organ failure assessment (qSOFA) criteria and the presence of an infectious disease based on a diagnosis made by a hospital physician of Imam Reza and Ghaemshahr of Mashhad in 2019. Demographic information of patients, SI score, RASI score, and information related to the patient's clinical symptoms were recorded in the checklist. The final outcome of this study was considered mortality. Data analysis was performed using descriptive and inferential tests. In the present study, a total of 178 patients, 46 patients (25.8%) were transferred to the intensive care unit, and 98 patients (55.1%) were admitted to the normal wards. Eighty-five patients (47.75%) died and the mean length of hospital stay of all patients was 11.07 ± 9.23 days. Forty-four patients (24.7%) had referred with a decreased level of consciousness and 44 patients (24.7%) presented with confusion. The rest of the patients reported normal levels of consciousness. Kaplan Mir analysis with log-rank was performed to determine the difference in survival distribution in different SI groups: Survival distribution was not statistically different for the four defined groups (based on statistical quartiles (P = 0.320). Receiver operator curves were considered as the date of death in the case of the deceased and the date of discharge from the hospital in the case of the living as censored. The AUC of the RASI scoring system for predicting mortality was 0.614 (P = 0.009) while this value was not significant for SI (P = 0.152). In logistic regression analysis, it was found that by adjusting for the variables of age, sex, sepsis etiology, blood pressure and heart rate, level of consciousness, and gender, patients with the lower respiratory rate (OR 1.6, z = −0.159 p = 0.007), younger age (OR 1.6, z = −0.029 p = 0.006) and higher RASI score are more in risk of mortality (OR 1.29, z = 1.209, p = 0.031). The results of our study showed that RASI scoring can be a good criterion for predicting the chance of mortality in patients with sepsis and could be used complementary to previous criteria such as SI. Patients with high RASI scores should be given more attention to reducing the chance of death. |
format | Online Article Text |
id | pubmed-9281559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92815592022-07-15 Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients Hashemian, Amir Masoud Baghshani, Zahra Farzaneh, Roohie Zamani Moghadam, Hamid Maleki, Fatemeh Bagherian, Farhad Ahmadnezhad, Somayyeh Foroughian, Mahdi Front Med (Lausanne) Medicine The aim of this study was to compare the relationship between shock index (SI) and respiratory adjusted shock index (RASI) scores with the final outcome of sepsis patients referred to the emergency department. This was prospective research that examined individuals who had been diagnosed with sepsis, determined by the presence of at least two of the three quick sepsis-related organ failure assessment (qSOFA) criteria and the presence of an infectious disease based on a diagnosis made by a hospital physician of Imam Reza and Ghaemshahr of Mashhad in 2019. Demographic information of patients, SI score, RASI score, and information related to the patient's clinical symptoms were recorded in the checklist. The final outcome of this study was considered mortality. Data analysis was performed using descriptive and inferential tests. In the present study, a total of 178 patients, 46 patients (25.8%) were transferred to the intensive care unit, and 98 patients (55.1%) were admitted to the normal wards. Eighty-five patients (47.75%) died and the mean length of hospital stay of all patients was 11.07 ± 9.23 days. Forty-four patients (24.7%) had referred with a decreased level of consciousness and 44 patients (24.7%) presented with confusion. The rest of the patients reported normal levels of consciousness. Kaplan Mir analysis with log-rank was performed to determine the difference in survival distribution in different SI groups: Survival distribution was not statistically different for the four defined groups (based on statistical quartiles (P = 0.320). Receiver operator curves were considered as the date of death in the case of the deceased and the date of discharge from the hospital in the case of the living as censored. The AUC of the RASI scoring system for predicting mortality was 0.614 (P = 0.009) while this value was not significant for SI (P = 0.152). In logistic regression analysis, it was found that by adjusting for the variables of age, sex, sepsis etiology, blood pressure and heart rate, level of consciousness, and gender, patients with the lower respiratory rate (OR 1.6, z = −0.159 p = 0.007), younger age (OR 1.6, z = −0.029 p = 0.006) and higher RASI score are more in risk of mortality (OR 1.29, z = 1.209, p = 0.031). The results of our study showed that RASI scoring can be a good criterion for predicting the chance of mortality in patients with sepsis and could be used complementary to previous criteria such as SI. Patients with high RASI scores should be given more attention to reducing the chance of death. Frontiers Media S.A. 2022-06-29 /pmc/articles/PMC9281559/ /pubmed/35847795 http://dx.doi.org/10.3389/fmed.2022.872725 Text en Copyright © 2022 Hashemian, Baghshani, Farzaneh, Zamani Moghadam, Maleki, Bagherian, Ahmadnezhad and Foroughian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Hashemian, Amir Masoud Baghshani, Zahra Farzaneh, Roohie Zamani Moghadam, Hamid Maleki, Fatemeh Bagherian, Farhad Ahmadnezhad, Somayyeh Foroughian, Mahdi Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title | Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title_full | Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title_fullStr | Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title_full_unstemmed | Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title_short | Comparison of the Relationship Between SI and RASI Scores With the Outcome of Sepsis Patients |
title_sort | comparison of the relationship between si and rasi scores with the outcome of sepsis patients |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281559/ https://www.ncbi.nlm.nih.gov/pubmed/35847795 http://dx.doi.org/10.3389/fmed.2022.872725 |
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