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Two HCN4 Channels Play Functional Roles in the Zebrafish Heart

The HCN4 channel is essential for heart rate regulation in vertebrates by generating pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause bradycardia and sick sinus syndrome, making it an important target for clinical research and drug discovery. The zebrafish is a popular...

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Detalles Bibliográficos
Autores principales: Liu, Jiaying, Kasuya, Go, Zempo, Buntaro, Nakajo, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281569/
https://www.ncbi.nlm.nih.gov/pubmed/35846012
http://dx.doi.org/10.3389/fphys.2022.901571