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Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study

Adipose tissue acts as an active endocrine organ secreting a number of adipokines and may be involved in biological mechanism of stroke. Vaspin, apelin, and visfatin play important roles in the regulation of vascular disorders. Our aim was to evaluate whether the concentrations of vaspin, apelin, an...

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Autores principales: Yu, Dalin, Huang, Bin, Wu, Bin, Xiao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281956/
https://www.ncbi.nlm.nih.gov/pubmed/33761698
http://dx.doi.org/10.1097/MD.0000000000025184
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author Yu, Dalin
Huang, Bin
Wu, Bin
Xiao, Jun
author_facet Yu, Dalin
Huang, Bin
Wu, Bin
Xiao, Jun
author_sort Yu, Dalin
collection PubMed
description Adipose tissue acts as an active endocrine organ secreting a number of adipokines and may be involved in biological mechanism of stroke. Vaspin, apelin, and visfatin play important roles in the regulation of vascular disorders. Our aim was to evaluate whether the concentrations of vaspin, apelin, and visfatin were associated with stroke risk. A total of 235 patients with stroke (156 patients with ischemic stroke and 79 patients with hemorrhagic stroke) and 235 age- and gender-matched healthy controls were included in this study. A sandwich ELISA was developed to measure the serum vaspin, apelin, and visfatin levels. There was a statistically significant difference in the median levels of serum vaspin, apelin, and visfatin levels between stroke cases and controls (vaspin: 1.50 vs 1.07 ng/ml; apelin: 1.56 vs 1.32 pg/ml; visfatin: 23.40 vs 19.65 ng/ml; all P values <.001). Multiple logistic regression analysis showed that, serum vaspin and visfatin levels were significantly inversely associated with increased risk of stroke, and the odds ratios (ORs) in the highest tertile were 2.25 [95% confidence interval (CI) 1.38–3.67; P for trend <.001] for vaspin and 2.56 (95% CI 1.46–4.47; P for trend <.001) for visfatin, respectively, compared with the lowest tertile. Higher apelin levels were marginally associated with lower stroke risk (P for trend =.060). Our study indicated that higher vaspin, apelin, and visfatin levels might be associated with increased stroke risk. Necessary prospective cohort studies should be conducted to confirm this association in the future.
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spelling pubmed-92819562022-08-02 Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study Yu, Dalin Huang, Bin Wu, Bin Xiao, Jun Medicine (Baltimore) 5300 Adipose tissue acts as an active endocrine organ secreting a number of adipokines and may be involved in biological mechanism of stroke. Vaspin, apelin, and visfatin play important roles in the regulation of vascular disorders. Our aim was to evaluate whether the concentrations of vaspin, apelin, and visfatin were associated with stroke risk. A total of 235 patients with stroke (156 patients with ischemic stroke and 79 patients with hemorrhagic stroke) and 235 age- and gender-matched healthy controls were included in this study. A sandwich ELISA was developed to measure the serum vaspin, apelin, and visfatin levels. There was a statistically significant difference in the median levels of serum vaspin, apelin, and visfatin levels between stroke cases and controls (vaspin: 1.50 vs 1.07 ng/ml; apelin: 1.56 vs 1.32 pg/ml; visfatin: 23.40 vs 19.65 ng/ml; all P values <.001). Multiple logistic regression analysis showed that, serum vaspin and visfatin levels were significantly inversely associated with increased risk of stroke, and the odds ratios (ORs) in the highest tertile were 2.25 [95% confidence interval (CI) 1.38–3.67; P for trend <.001] for vaspin and 2.56 (95% CI 1.46–4.47; P for trend <.001) for visfatin, respectively, compared with the lowest tertile. Higher apelin levels were marginally associated with lower stroke risk (P for trend =.060). Our study indicated that higher vaspin, apelin, and visfatin levels might be associated with increased stroke risk. Necessary prospective cohort studies should be conducted to confirm this association in the future. Lippincott Williams & Wilkins 2021-03-26 /pmc/articles/PMC9281956/ /pubmed/33761698 http://dx.doi.org/10.1097/MD.0000000000025184 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 5300
Yu, Dalin
Huang, Bin
Wu, Bin
Xiao, Jun
Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title_full Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title_fullStr Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title_full_unstemmed Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title_short Association of serum vaspin, apelin, and visfatin levels and stroke risk in a Chinese case-control study
title_sort association of serum vaspin, apelin, and visfatin levels and stroke risk in a chinese case-control study
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281956/
https://www.ncbi.nlm.nih.gov/pubmed/33761698
http://dx.doi.org/10.1097/MD.0000000000025184
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