The methyltransferase enzymes KMT2D, SETD1B, and ASH1L are key mediators of both metabolic and epigenetic changes during cellular senescence

Cellular senescence is a terminal cell fate characterized by growth arrest and a metabolically active state characterized by high glycolytic activity. Human fibroblasts were placed in a unique metabolic state using a combination of methionine restriction (MetR) and rapamycin (Rapa). This combination...

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Detalles Bibliográficos
Autores principales: Nacarelli, Timothy, Azar, Ashley, Potnis, Manali, Johannes, Gregg, Mell, Joshua, Johnson, F. Brad, Brown-Borg, Holly, Noguchi, Eishi, Sell, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282020/
https://www.ncbi.nlm.nih.gov/pubmed/35196069
http://dx.doi.org/10.1091/mbc.E20-08-0523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282020/
https://www.ncbi.nlm.nih.gov/pubmed/35196069
http://dx.doi.org/10.1091/mbc.E20-08-0523

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