Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis when routine clinical tests fail to provide a definitive diagnosis....

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Detalles Bibliográficos
Autores principales: Guan, Qingtian, Alhuthali, Bushra, Mfarrej, Sara, Halim, Magid Abdel, Almaghrabi, Reem S, Pain, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Pearls
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282092/
https://www.ncbi.nlm.nih.gov/pubmed/34738616
http://dx.doi.org/10.1093/jtm/taab172
Descripción
Sumario:We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.

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