Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis when routine clinical tests fail to provide a definitive diagnosis....

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Autores principales: Guan, Qingtian, Alhuthali, Bushra, Mfarrej, Sara, Halim, Magid Abdel, Almaghrabi, Reem S, Pain, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Pearls
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282092/
https://www.ncbi.nlm.nih.gov/pubmed/34738616
http://dx.doi.org/10.1093/jtm/taab172
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author Guan, Qingtian
Alhuthali, Bushra
Mfarrej, Sara
Halim, Magid Abdel
Almaghrabi, Reem S
Pain, Arnab
author_facet Guan, Qingtian
Alhuthali, Bushra
Mfarrej, Sara
Halim, Magid Abdel
Almaghrabi, Reem S
Pain, Arnab
author_sort Guan, Qingtian
collection PubMed
description We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.
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spelling pubmed-92820922022-07-18 Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis Guan, Qingtian Alhuthali, Bushra Mfarrej, Sara Halim, Magid Abdel Almaghrabi, Reem S Pain, Arnab J Travel Med Clinical Pearls We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome. Oxford University Press 2021-11-05 /pmc/articles/PMC9282092/ /pubmed/34738616 http://dx.doi.org/10.1093/jtm/taab172 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of International Society of Travel Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Pearls
Guan, Qingtian
Alhuthali, Bushra
Mfarrej, Sara
Halim, Magid Abdel
Almaghrabi, Reem S
Pain, Arnab
Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title_full Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title_fullStr Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title_full_unstemmed Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title_short Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
title_sort metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis
topic Clinical Pearls
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282092/
https://www.ncbi.nlm.nih.gov/pubmed/34738616
http://dx.doi.org/10.1093/jtm/taab172
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