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Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk
Donkey milk (DM), similar to human milk (HM) in chemical composition, has been suggested as the best potential hypoallergenic replacement diet for babies suffering from Cow milk (CM) protein allergy. In order to better understand DM protein, many studies based on proteomic have been performed. In th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282231/ https://www.ncbi.nlm.nih.gov/pubmed/35845789 http://dx.doi.org/10.3389/fnut.2022.911454 |
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author | Zhang, Xinhao Jiang, Guimiao Ji, Chuanliang Fan, Zhaobin Ge, Shihao Li, Haijing Wang, Yantao Lv, Xin Zhao, Fuwei |
author_facet | Zhang, Xinhao Jiang, Guimiao Ji, Chuanliang Fan, Zhaobin Ge, Shihao Li, Haijing Wang, Yantao Lv, Xin Zhao, Fuwei |
author_sort | Zhang, Xinhao |
collection | PubMed |
description | Donkey milk (DM), similar to human milk (HM) in chemical composition, has been suggested as the best potential hypoallergenic replacement diet for babies suffering from Cow milk (CM) protein allergy. In order to better understand DM protein, many studies based on proteomic have been performed. In this study, the label-free quantitative proteomic approach was conducted to quantitatively identify the differentially expressed whey proteins (DEPs) in DM vs. HM group and DM vs. CM group. In total, 241 and 365 DEPs were found in these two groups, respectively. Bioinformatics analysis of DEPs showed that the majority of DEPs participated in the lipoprotein metabolic process, regulation of cytokine production, chemical homeostasis, and catabolic process. The Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways analysis found that these DEPs mainly participated in an antigen processing, complement, and coagulation cascades. These results may provide valuable information in the composition of milk whey proteins in DM, HM, and CM, especially for low abundant components, and expand our knowledge of different biological functions between DM and HM or CM. |
format | Online Article Text |
id | pubmed-9282231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92822312022-07-15 Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk Zhang, Xinhao Jiang, Guimiao Ji, Chuanliang Fan, Zhaobin Ge, Shihao Li, Haijing Wang, Yantao Lv, Xin Zhao, Fuwei Front Nutr Nutrition Donkey milk (DM), similar to human milk (HM) in chemical composition, has been suggested as the best potential hypoallergenic replacement diet for babies suffering from Cow milk (CM) protein allergy. In order to better understand DM protein, many studies based on proteomic have been performed. In this study, the label-free quantitative proteomic approach was conducted to quantitatively identify the differentially expressed whey proteins (DEPs) in DM vs. HM group and DM vs. CM group. In total, 241 and 365 DEPs were found in these two groups, respectively. Bioinformatics analysis of DEPs showed that the majority of DEPs participated in the lipoprotein metabolic process, regulation of cytokine production, chemical homeostasis, and catabolic process. The Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways analysis found that these DEPs mainly participated in an antigen processing, complement, and coagulation cascades. These results may provide valuable information in the composition of milk whey proteins in DM, HM, and CM, especially for low abundant components, and expand our knowledge of different biological functions between DM and HM or CM. Frontiers Media S.A. 2022-06-27 /pmc/articles/PMC9282231/ /pubmed/35845789 http://dx.doi.org/10.3389/fnut.2022.911454 Text en Copyright © 2022 Zhang, Jiang, Ji, Fan, Ge, Li, Wang, Lv and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Zhang, Xinhao Jiang, Guimiao Ji, Chuanliang Fan, Zhaobin Ge, Shihao Li, Haijing Wang, Yantao Lv, Xin Zhao, Fuwei Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title | Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title_full | Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title_fullStr | Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title_full_unstemmed | Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title_short | Comparative Whey Proteome Profiling of Donkey Milk With Human and Cow Milk |
title_sort | comparative whey proteome profiling of donkey milk with human and cow milk |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282231/ https://www.ncbi.nlm.nih.gov/pubmed/35845789 http://dx.doi.org/10.3389/fnut.2022.911454 |
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