Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics

Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a wide range of traits using summary statistics from genome-wide association studies (GWASs). Existing summary-level MR methods often rely on strong assumptions, resulting in many false-positive findings. To rel...

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Detalles Bibliográficos
Autores principales: Hu, Xianghong, Zhao, Jia, Lin, Zhixiang, Wang, Yang, Peng, Heng, Zhao, Hongyu, Wan, Xiang, Yang, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282238/
https://www.ncbi.nlm.nih.gov/pubmed/35787050
http://dx.doi.org/10.1073/pnas.2106858119

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