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Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes
CONTEXT: Calorie restriction plus dietary advice is suggested as a preventive strategy for individuals with obesity and prediabetes; however, optimal diet is still debatable. We aimed to compare the effects of Mediterranean diet (MD) and Chinese diets high or low in plants on body weight and glucose...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282247/ https://www.ncbi.nlm.nih.gov/pubmed/35579171 http://dx.doi.org/10.1210/clinem/dgac303 |
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author | Luo, Yaogan Wang, Jiqiu Sun, Liang Gu, Weiqiong Zong, Geng Song, Boyu Shen, Chongrong Zhou, Puchen Chen, Yufei Wu, Yanpu Lin, Huibin Zheng, He Ni, Mengshan Yang, Xiaowei Chen, Yanru Xu, Xinming Zhang, Juan Shi, Juan Zhang, Ru Hu, Jinfen Hou, Hong Lu, Ling Xu, Xiaoqiang Liang, Liming Liu, Ruixin Liu, Xiaoran Li, Huaixing Hong, Jie Wang, Weiqing Lin, Xu Ning, Guang |
author_facet | Luo, Yaogan Wang, Jiqiu Sun, Liang Gu, Weiqiong Zong, Geng Song, Boyu Shen, Chongrong Zhou, Puchen Chen, Yufei Wu, Yanpu Lin, Huibin Zheng, He Ni, Mengshan Yang, Xiaowei Chen, Yanru Xu, Xinming Zhang, Juan Shi, Juan Zhang, Ru Hu, Jinfen Hou, Hong Lu, Ling Xu, Xiaoqiang Liang, Liming Liu, Ruixin Liu, Xiaoran Li, Huaixing Hong, Jie Wang, Weiqing Lin, Xu Ning, Guang |
author_sort | Luo, Yaogan |
collection | PubMed |
description | CONTEXT: Calorie restriction plus dietary advice is suggested as a preventive strategy for individuals with obesity and prediabetes; however, optimal diet is still debatable. We aimed to compare the effects of Mediterranean diet (MD) and Chinese diets high or low in plants on body weight and glucose homeostasis among high-risk Chinese. SUBJECTS AND METHODS: In this parallel-arm randomized controlled trial, 253 Chinese adults aged 25 to 60 years with a body mass index ≥ 24.0 kg/m(2) and fasting blood glucose ≥ 5.6 mmol/L were randomly assigned to 3 isocaloric-restricted diets: MD (n = 84), a traditional Jiangnan diet high in plants (TJD, n = 85), or a control diet low in plants (CD, n = 84). During the 6-month trial, a 5-weekday full-feeding regimen was followed, along with mobile app–based monitoring. Abdominal fat measurement (magnetic resonance imaging), oral glucose tolerance test (OGTT), and continuous glucose monitoring (CGM) were conducted at baseline and 3 and 6 months. RESULTS: With a 25% calorie restriction for 6 months, weight deduction was 5.72 kg (95% confidence interval, 5.03-6.40) for MD, 5.05 kg (4.38-5.73) for TJD, and 5.38 kg (4.70-6.06) for CD (P(time) < 0.0001). No between-group differences were found for fasting glucose, insulin, and the Matsuda index from OGTT. Notably, CD had significantly longer time below range (glucose < 3.9 mmol/L) than MD (0.81% [0.21-1.40], P = 0.024) and marginally longer time than TJD (0.56% [-0.03 to 1.15], P = 0.065), as measured by CGM. CONCLUSIONS: With the 6-month isocaloric-restricted feeding, TJD and MD achieved comparable weight deduction and improved glucose homeostasis, whereas CD showed a higher risk for hypoglycemia. |
format | Online Article Text |
id | pubmed-9282247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92822472022-07-18 Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes Luo, Yaogan Wang, Jiqiu Sun, Liang Gu, Weiqiong Zong, Geng Song, Boyu Shen, Chongrong Zhou, Puchen Chen, Yufei Wu, Yanpu Lin, Huibin Zheng, He Ni, Mengshan Yang, Xiaowei Chen, Yanru Xu, Xinming Zhang, Juan Shi, Juan Zhang, Ru Hu, Jinfen Hou, Hong Lu, Ling Xu, Xiaoqiang Liang, Liming Liu, Ruixin Liu, Xiaoran Li, Huaixing Hong, Jie Wang, Weiqing Lin, Xu Ning, Guang J Clin Endocrinol Metab Clinical Research Article CONTEXT: Calorie restriction plus dietary advice is suggested as a preventive strategy for individuals with obesity and prediabetes; however, optimal diet is still debatable. We aimed to compare the effects of Mediterranean diet (MD) and Chinese diets high or low in plants on body weight and glucose homeostasis among high-risk Chinese. SUBJECTS AND METHODS: In this parallel-arm randomized controlled trial, 253 Chinese adults aged 25 to 60 years with a body mass index ≥ 24.0 kg/m(2) and fasting blood glucose ≥ 5.6 mmol/L were randomly assigned to 3 isocaloric-restricted diets: MD (n = 84), a traditional Jiangnan diet high in plants (TJD, n = 85), or a control diet low in plants (CD, n = 84). During the 6-month trial, a 5-weekday full-feeding regimen was followed, along with mobile app–based monitoring. Abdominal fat measurement (magnetic resonance imaging), oral glucose tolerance test (OGTT), and continuous glucose monitoring (CGM) were conducted at baseline and 3 and 6 months. RESULTS: With a 25% calorie restriction for 6 months, weight deduction was 5.72 kg (95% confidence interval, 5.03-6.40) for MD, 5.05 kg (4.38-5.73) for TJD, and 5.38 kg (4.70-6.06) for CD (P(time) < 0.0001). No between-group differences were found for fasting glucose, insulin, and the Matsuda index from OGTT. Notably, CD had significantly longer time below range (glucose < 3.9 mmol/L) than MD (0.81% [0.21-1.40], P = 0.024) and marginally longer time than TJD (0.56% [-0.03 to 1.15], P = 0.065), as measured by CGM. CONCLUSIONS: With the 6-month isocaloric-restricted feeding, TJD and MD achieved comparable weight deduction and improved glucose homeostasis, whereas CD showed a higher risk for hypoglycemia. Oxford University Press 2022-05-17 /pmc/articles/PMC9282247/ /pubmed/35579171 http://dx.doi.org/10.1210/clinem/dgac303 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Research Article Luo, Yaogan Wang, Jiqiu Sun, Liang Gu, Weiqiong Zong, Geng Song, Boyu Shen, Chongrong Zhou, Puchen Chen, Yufei Wu, Yanpu Lin, Huibin Zheng, He Ni, Mengshan Yang, Xiaowei Chen, Yanru Xu, Xinming Zhang, Juan Shi, Juan Zhang, Ru Hu, Jinfen Hou, Hong Lu, Ling Xu, Xiaoqiang Liang, Liming Liu, Ruixin Liu, Xiaoran Li, Huaixing Hong, Jie Wang, Weiqing Lin, Xu Ning, Guang Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title | Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title_full | Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title_fullStr | Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title_full_unstemmed | Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title_short | Isocaloric-restricted Mediterranean Diet and Chinese Diets High or Low in Plants in Adults With Prediabetes |
title_sort | isocaloric-restricted mediterranean diet and chinese diets high or low in plants in adults with prediabetes |
topic | Clinical Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282247/ https://www.ncbi.nlm.nih.gov/pubmed/35579171 http://dx.doi.org/10.1210/clinem/dgac303 |
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