Factors Compromising Glucuronidase Performance in Urine Drug Testing Potentially Resulting in False Negatives

Next generation β-glucuronidases can effectively cleave glucuronides in urine at room temperature. However, during the discovery studies, additional challenges were identified for urine drug testing across biologically relevant pH extremes and patient urine specimens. Different enzymes were evaluate...

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Detalles Bibliográficos
Autores principales: Lee, L Andrew, McGee, Amanda C, Sitasuwan, Pongkwan, Tomashek, John J, Riley, Chris, Muñoz-Muñoz, Ana Celia, Andrade, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282255/
https://www.ncbi.nlm.nih.gov/pubmed/34401904
http://dx.doi.org/10.1093/jat/bkab090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282255/
https://www.ncbi.nlm.nih.gov/pubmed/34401904
http://dx.doi.org/10.1093/jat/bkab090

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