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Impaired Brain Satiety Responses After Weight Loss in Children With Obesity

CONTEXT: Obesity interventions often result in increased motivation to eat. OBJECTIVE: We investigated relationships between obesity outcomes and changes in brain activation by visual food cues and hormone levels in response to obesity intervention by family-based behavioral treatment (FBT). METHODS...

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Autores principales: Roth, Christian L, Melhorn, Susan J, De Leon, Mary Rosalynn B, Rowland, Maya G, Elfers, Clinton T, Huang, Alyssa, Saelens, Brian E, Schur, Ellen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282278/
https://www.ncbi.nlm.nih.gov/pubmed/35544121
http://dx.doi.org/10.1210/clinem/dgac299
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author Roth, Christian L
Melhorn, Susan J
De Leon, Mary Rosalynn B
Rowland, Maya G
Elfers, Clinton T
Huang, Alyssa
Saelens, Brian E
Schur, Ellen A
author_facet Roth, Christian L
Melhorn, Susan J
De Leon, Mary Rosalynn B
Rowland, Maya G
Elfers, Clinton T
Huang, Alyssa
Saelens, Brian E
Schur, Ellen A
author_sort Roth, Christian L
collection PubMed
description CONTEXT: Obesity interventions often result in increased motivation to eat. OBJECTIVE: We investigated relationships between obesity outcomes and changes in brain activation by visual food cues and hormone levels in response to obesity intervention by family-based behavioral treatment (FBT). METHODS: Neuroimaging and hormone assessments were conducted before and after 24-week FBT intervention in children with obesity (OB, n = 28), or children of healthy weight without intervention (HW, n = 17), all 9- to 11-year-old boys and girls. We evaluated meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions and gut hormones. RESULTS: Among children with OB who underwent FBT, greater declines of BMI z-score were associated with lesser reductions after the FBT intervention in meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions (P < 0.05), and the slope of relationship was significantly different compared with children of HW. In children with OB, less reduction in brain responses to a meal from before to after FBT was associated with greater meal-induced reduction in ghrelin and increased meal-induced stimulation in peptide YY and glucagon-like peptide-1 (all P < 0.05). CONCLUSION: In response to FBT, adaptations of central satiety responses and peripheral satiety-regulating hormones were noted. After weight loss, changes of peripheral hormone secretion support weight loss, but there was a weaker central satiety response. The findings suggest that even when peripheral satiety responses by gut hormones are intact, the central regulation of satiety is disturbed in children with OB who significantly improve their weight status during FBT, which could favor future weight regain.
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spelling pubmed-92822782022-07-18 Impaired Brain Satiety Responses After Weight Loss in Children With Obesity Roth, Christian L Melhorn, Susan J De Leon, Mary Rosalynn B Rowland, Maya G Elfers, Clinton T Huang, Alyssa Saelens, Brian E Schur, Ellen A J Clin Endocrinol Metab Clinical Research Article CONTEXT: Obesity interventions often result in increased motivation to eat. OBJECTIVE: We investigated relationships between obesity outcomes and changes in brain activation by visual food cues and hormone levels in response to obesity intervention by family-based behavioral treatment (FBT). METHODS: Neuroimaging and hormone assessments were conducted before and after 24-week FBT intervention in children with obesity (OB, n = 28), or children of healthy weight without intervention (HW, n = 17), all 9- to 11-year-old boys and girls. We evaluated meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions and gut hormones. RESULTS: Among children with OB who underwent FBT, greater declines of BMI z-score were associated with lesser reductions after the FBT intervention in meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions (P < 0.05), and the slope of relationship was significantly different compared with children of HW. In children with OB, less reduction in brain responses to a meal from before to after FBT was associated with greater meal-induced reduction in ghrelin and increased meal-induced stimulation in peptide YY and glucagon-like peptide-1 (all P < 0.05). CONCLUSION: In response to FBT, adaptations of central satiety responses and peripheral satiety-regulating hormones were noted. After weight loss, changes of peripheral hormone secretion support weight loss, but there was a weaker central satiety response. The findings suggest that even when peripheral satiety responses by gut hormones are intact, the central regulation of satiety is disturbed in children with OB who significantly improve their weight status during FBT, which could favor future weight regain. Oxford University Press 2022-05-11 /pmc/articles/PMC9282278/ /pubmed/35544121 http://dx.doi.org/10.1210/clinem/dgac299 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Research Article
Roth, Christian L
Melhorn, Susan J
De Leon, Mary Rosalynn B
Rowland, Maya G
Elfers, Clinton T
Huang, Alyssa
Saelens, Brian E
Schur, Ellen A
Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title_full Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title_fullStr Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title_full_unstemmed Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title_short Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
title_sort impaired brain satiety responses after weight loss in children with obesity
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282278/
https://www.ncbi.nlm.nih.gov/pubmed/35544121
http://dx.doi.org/10.1210/clinem/dgac299
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