An immature, dedifferentiated, and lineage-deconstrained cone precursor origin of N-Myc–initiated retinoblastoma

Most retinoblastomas develop from maturing cone precursors in response to biallelic RB1 loss and are dependent on cone maturation-related signaling. Additionally, ∼2% lack RB1 mutations but have MYCN amplification (MYCN(A)), N-Myc protein overexpression, and more rapid and invasive growth, yet the M...

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Detalles Bibliográficos
Autores principales: Singh, Hardeep P., Shayler, Dominic W. H., Fernandez, G. Esteban, Thornton, Matthew E., Craft, Cheryl Mae, Grubbs, Brendan H., Cobrinik, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282279/
https://www.ncbi.nlm.nih.gov/pubmed/35867756
http://dx.doi.org/10.1073/pnas.2200721119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282279/
https://www.ncbi.nlm.nih.gov/pubmed/35867756
http://dx.doi.org/10.1073/pnas.2200721119

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