Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined. Because lysophosphatidic acid is a mediator of fibrosis in multiple organs and diseases, we tested the ro...

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Detalles Bibliográficos
Autores principales: Axelsson Raja, Anna, Wakimoto, Hiroko, DeLaughter, Daniel M., Reichart, Daniel, Gorham, Joshua, Conner, David A., Lun, Mingyue, Probst, Clemens K., Sakai, Norihiko, Knipe, Rachel S., Montesi, Sydney B., Shea, Barry, Adam, Leonard P., Leinwand, Leslie A., Wan, William, Choi, Esther Sue, Lindberg, Eric L., Patone, Giannino, Noseda, Michela, Hübner, Norbert, Seidman, Christine E., Tager, Andrew M., Seidman, J. G., Ho, Carolyn Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282378/
https://www.ncbi.nlm.nih.gov/pubmed/35787042
http://dx.doi.org/10.1073/pnas.2204174119

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