Adenosine A(2A) receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function

Chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medical problem without therapeutic options. Using the platinum-based chemotherapy cisplatin to model CICI, we revealed robust elevations in the adenosine A(2A) receptor (A(2A)R) and its downstream effectors, cAMP and CREB...

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Detalles Bibliográficos
Autores principales: Oliveros, Alfredo, Yoo, Ki Hyun, Rashid, Mohammad Abdur, Corujo-Ramirez, Ana, Hur, Benjamin, Sung, Jaeyun, Liu, Yuanhang, Hawse, John R., Choi, Doo-Sup, Boison, Detlev, Jang, Mi-Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282426/
https://www.ncbi.nlm.nih.gov/pubmed/35867768
http://dx.doi.org/10.1073/pnas.2206415119

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