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Adaptation of the infant gut microbiome during the complementary feeding transition

The infant gut microbiome progresses in composition and function during the introduction of solid foods throughout the first year of life. The purpose of this study was to characterize changes in healthy infant gut microbiome composition, metagenomic functional capacity, and associated metabolites o...

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Autores principales: McKeen, Starin, Roy, Nicole C., Mullaney, Jane Adair, Eriksen, Hannah, Lovell, Amy, Kussman, Martin, Young, Wayne, Fraser, Karl, Wall, Clare R., McNabb, Warren C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282554/
https://www.ncbi.nlm.nih.gov/pubmed/35834499
http://dx.doi.org/10.1371/journal.pone.0270213
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author McKeen, Starin
Roy, Nicole C.
Mullaney, Jane Adair
Eriksen, Hannah
Lovell, Amy
Kussman, Martin
Young, Wayne
Fraser, Karl
Wall, Clare R.
McNabb, Warren C.
author_facet McKeen, Starin
Roy, Nicole C.
Mullaney, Jane Adair
Eriksen, Hannah
Lovell, Amy
Kussman, Martin
Young, Wayne
Fraser, Karl
Wall, Clare R.
McNabb, Warren C.
author_sort McKeen, Starin
collection PubMed
description The infant gut microbiome progresses in composition and function during the introduction of solid foods throughout the first year of life. The purpose of this study was to characterize changes in healthy infant gut microbiome composition, metagenomic functional capacity, and associated metabolites over the course of the complementary feeding period. Fecal samples were obtained at three ‘snapshot’ timepoints from infants participating in the ‘Nourish to Flourish’ pilot study: before the introduction of solid foods at approximately 4 months of age, after introducing solid foods at 9 months of age, and after continued diet diversification at 12 months of age. KEGG and taxonomy assignments were correlated with LC-MS metabolomic profiles to identify patterns of co-abundance. The composition of the microbiome diversified during the first year of life, while the functional capacity present in the gut microbiome remained stable. The introduction of solid foods between 4 and 9 months of age corresponded to a larger magnitude of change in relative abundance of sequences assigned to KEGG pathways and taxonomic assignments, as well as to stronger correlations with metabolites, compared to the magnitude of changes and number of correlations seen during continued diet diversification between 9 and 12 months of age. Changes in aqueous fecal metabolites were more strongly correlated with KEGG pathway assignments, while changes in lipid metabolites associated with taxonomic assignments, particularly between 9 and 12 months of age. This study establishes trends in microbiome composition and functional capacity occurring during the complementary feeding period and identifies potential metabolite targets for future investigations.
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spelling pubmed-92825542022-07-15 Adaptation of the infant gut microbiome during the complementary feeding transition McKeen, Starin Roy, Nicole C. Mullaney, Jane Adair Eriksen, Hannah Lovell, Amy Kussman, Martin Young, Wayne Fraser, Karl Wall, Clare R. McNabb, Warren C. PLoS One Research Article The infant gut microbiome progresses in composition and function during the introduction of solid foods throughout the first year of life. The purpose of this study was to characterize changes in healthy infant gut microbiome composition, metagenomic functional capacity, and associated metabolites over the course of the complementary feeding period. Fecal samples were obtained at three ‘snapshot’ timepoints from infants participating in the ‘Nourish to Flourish’ pilot study: before the introduction of solid foods at approximately 4 months of age, after introducing solid foods at 9 months of age, and after continued diet diversification at 12 months of age. KEGG and taxonomy assignments were correlated with LC-MS metabolomic profiles to identify patterns of co-abundance. The composition of the microbiome diversified during the first year of life, while the functional capacity present in the gut microbiome remained stable. The introduction of solid foods between 4 and 9 months of age corresponded to a larger magnitude of change in relative abundance of sequences assigned to KEGG pathways and taxonomic assignments, as well as to stronger correlations with metabolites, compared to the magnitude of changes and number of correlations seen during continued diet diversification between 9 and 12 months of age. Changes in aqueous fecal metabolites were more strongly correlated with KEGG pathway assignments, while changes in lipid metabolites associated with taxonomic assignments, particularly between 9 and 12 months of age. This study establishes trends in microbiome composition and functional capacity occurring during the complementary feeding period and identifies potential metabolite targets for future investigations. Public Library of Science 2022-07-14 /pmc/articles/PMC9282554/ /pubmed/35834499 http://dx.doi.org/10.1371/journal.pone.0270213 Text en © 2022 McKeen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
McKeen, Starin
Roy, Nicole C.
Mullaney, Jane Adair
Eriksen, Hannah
Lovell, Amy
Kussman, Martin
Young, Wayne
Fraser, Karl
Wall, Clare R.
McNabb, Warren C.
Adaptation of the infant gut microbiome during the complementary feeding transition
title Adaptation of the infant gut microbiome during the complementary feeding transition
title_full Adaptation of the infant gut microbiome during the complementary feeding transition
title_fullStr Adaptation of the infant gut microbiome during the complementary feeding transition
title_full_unstemmed Adaptation of the infant gut microbiome during the complementary feeding transition
title_short Adaptation of the infant gut microbiome during the complementary feeding transition
title_sort adaptation of the infant gut microbiome during the complementary feeding transition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282554/
https://www.ncbi.nlm.nih.gov/pubmed/35834499
http://dx.doi.org/10.1371/journal.pone.0270213
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