A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

Tubulointerstitial nephritis with uveitis (TINU) is an uncommon autoimmune syndrome that involves multiple systems. It usually presents with acute kidney injury (AKI) and unilateral or bilateral uveitis. We present a 15-year-old male, fit and well, who attended emergency room (ER) with a four-month...

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Autores principales: Iqbal, Junaid, Alassafi, Mohammed T, Alashaikh, Faisal M, Alhafi, Mohammed M, Abohaimid, Abdulrahman N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282581/
https://www.ncbi.nlm.nih.gov/pubmed/35844326
http://dx.doi.org/10.7759/cureus.25927
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author Iqbal, Junaid
Alassafi, Mohammed T
Alashaikh, Faisal M
Alhafi, Mohammed M
Abohaimid, Abdulrahman N
author_facet Iqbal, Junaid
Alassafi, Mohammed T
Alashaikh, Faisal M
Alhafi, Mohammed M
Abohaimid, Abdulrahman N
author_sort Iqbal, Junaid
collection PubMed
description Tubulointerstitial nephritis with uveitis (TINU) is an uncommon autoimmune syndrome that involves multiple systems. It usually presents with acute kidney injury (AKI) and unilateral or bilateral uveitis. We present a 15-year-old male, fit and well, who attended emergency room (ER) with a four-month history of epigastric pain associated with nausea, vomiting, and weight loss of 10 kg. Initial clinical and laboratory evaluation confirmed AKI. A diagnostic kidney biopsy confirmed acute tubulointerstitial nephritis, and a slit-lamp examination confirmed acute left anterior uveitis consistent with a diagnosis of TINU. He was initially treated with corticosteroids which resulted in prompt resolution of AKI; however, uveitis persisted necessitating the addition of further immunosuppressants.
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spelling pubmed-92825812022-07-15 A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report Iqbal, Junaid Alassafi, Mohammed T Alashaikh, Faisal M Alhafi, Mohammed M Abohaimid, Abdulrahman N Cureus Internal Medicine Tubulointerstitial nephritis with uveitis (TINU) is an uncommon autoimmune syndrome that involves multiple systems. It usually presents with acute kidney injury (AKI) and unilateral or bilateral uveitis. We present a 15-year-old male, fit and well, who attended emergency room (ER) with a four-month history of epigastric pain associated with nausea, vomiting, and weight loss of 10 kg. Initial clinical and laboratory evaluation confirmed AKI. A diagnostic kidney biopsy confirmed acute tubulointerstitial nephritis, and a slit-lamp examination confirmed acute left anterior uveitis consistent with a diagnosis of TINU. He was initially treated with corticosteroids which resulted in prompt resolution of AKI; however, uveitis persisted necessitating the addition of further immunosuppressants. Cureus 2022-06-14 /pmc/articles/PMC9282581/ /pubmed/35844326 http://dx.doi.org/10.7759/cureus.25927 Text en Copyright © 2022, Iqbal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Iqbal, Junaid
Alassafi, Mohammed T
Alashaikh, Faisal M
Alhafi, Mohammed M
Abohaimid, Abdulrahman N
A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title_full A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title_fullStr A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title_full_unstemmed A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title_short A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report
title_sort young man with acute kidney injury and uveitis: an unusual presentation and case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282581/
https://www.ncbi.nlm.nih.gov/pubmed/35844326
http://dx.doi.org/10.7759/cureus.25927
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