Alpha globin gene copy number and hypertension risk among Black Americans

BACKGROUND: Alpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin gene (HBA) is common among Black Americans and could lead to increa...

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Detalles Bibliográficos
Autores principales: Ruhl, A. Parker, Jeffries, Neal, Yang, Yu, Gutierrez, Orlando M., Muntner, Paul, Naik, Rakhi P., Pecker, Lydia H., Mott, Bryan T., Zakai, Neil A., Safford, Monika M., Lange, Leslie A., Winkler, Cheryl A., Irvin, Marguerite R., Cushman, Mary, Ackerman, Hans C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282593/
https://www.ncbi.nlm.nih.gov/pubmed/35834496
http://dx.doi.org/10.1371/journal.pone.0271031

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