Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization

A quantitative determination method for Al(3+) in immunobiological drugs using atomic absorption spectroscopy with electrothermal atomization was developed. Conditions for the preparation of aluminum hydroxide gel were selected [NaOH (5 M), heating in a boiling-water bath for 5 min followed by neutralization with conc. HNO(3)]. The method was validated. The analytical range of Al(3+) was established in the interval 10 – 50 ig/L. The accuracy and in-laboratory precision were confirmed. The results allowed the proposed method to be considered an alternative for quantitative determination of Al(3+) in immunobiological drugs.