Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization

A quantitative determination method for Al(3+) in immunobiological drugs using atomic absorption spectroscopy with electrothermal atomization was developed. Conditions for the preparation of aluminum hydroxide gel were selected [NaOH (5 M), heating in a boiling-water bath for 5 min followed by neutr...

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Autores principales: Makarishcheva, D. D., Kolesnikova, O. N., Tregubova, V. E., Ustinnikova, O. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282627/
https://www.ncbi.nlm.nih.gov/pubmed/35854791
http://dx.doi.org/10.1007/s11094-022-02669-0
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author Makarishcheva, D. D.
Kolesnikova, O. N.
Tregubova, V. E.
Ustinnikova, O. B.
author_facet Makarishcheva, D. D.
Kolesnikova, O. N.
Tregubova, V. E.
Ustinnikova, O. B.
author_sort Makarishcheva, D. D.
collection PubMed
description A quantitative determination method for Al(3+) in immunobiological drugs using atomic absorption spectroscopy with electrothermal atomization was developed. Conditions for the preparation of aluminum hydroxide gel were selected [NaOH (5 M), heating in a boiling-water bath for 5 min followed by neutralization with conc. HNO(3)]. The method was validated. The analytical range of Al(3+) was established in the interval 10 – 50 ig/L. The accuracy and in-laboratory precision were confirmed. The results allowed the proposed method to be considered an alternative for quantitative determination of Al(3+) in immunobiological drugs.
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spelling pubmed-92826272022-07-15 Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization Makarishcheva, D. D. Kolesnikova, O. N. Tregubova, V. E. Ustinnikova, O. B. Pharm Chem J Article A quantitative determination method for Al(3+) in immunobiological drugs using atomic absorption spectroscopy with electrothermal atomization was developed. Conditions for the preparation of aluminum hydroxide gel were selected [NaOH (5 M), heating in a boiling-water bath for 5 min followed by neutralization with conc. HNO(3)]. The method was validated. The analytical range of Al(3+) was established in the interval 10 – 50 ig/L. The accuracy and in-laboratory precision were confirmed. The results allowed the proposed method to be considered an alternative for quantitative determination of Al(3+) in immunobiological drugs. Springer US 2022-07-09 2022 /pmc/articles/PMC9282627/ /pubmed/35854791 http://dx.doi.org/10.1007/s11094-022-02669-0 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Makarishcheva, D. D.
Kolesnikova, O. N.
Tregubova, V. E.
Ustinnikova, O. B.
Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title_full Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title_fullStr Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title_full_unstemmed Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title_short Development of a Quantitative Determination Method for Aluminum Ions in Adsorbed Drugs Using Atomic Absorption Spectrometry with Electrothermal Atomization
title_sort development of a quantitative determination method for aluminum ions in adsorbed drugs using atomic absorption spectrometry with electrothermal atomization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282627/
https://www.ncbi.nlm.nih.gov/pubmed/35854791
http://dx.doi.org/10.1007/s11094-022-02669-0
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