High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes

[Image: see text] The effectiveness of β-lactam antibiotics is increasingly compromised by β-lactamases. Boron-containing inhibitors are potent serine-β-lactamase inhibitors, but the interactions of boron-based compounds with the penicillin-binding protein (PBP) β-lactam targets have not been extens...

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Detalles Bibliográficos
Autores principales: Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J., Boyle, Grant A., Paterson, Neil G., McAuley, Katherine E., Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, Jürgen, Chibale, Kelly, Schofield, Christopher J., Dowson, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282634/
https://www.ncbi.nlm.nih.gov/pubmed/34337941
http://dx.doi.org/10.1021/acs.jmedchem.1c00717

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