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Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis

Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the und...

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Autores principales: Zhai, Ganggang, Xiao, Likang, Jiang, Chenyang, Yue, Songkai, Zhang, Meng, zheng, Jia, Liu, Zeming, Dong, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282717/
https://www.ncbi.nlm.nih.gov/pubmed/35846376
http://dx.doi.org/10.3389/fcell.2022.946219
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author Zhai, Ganggang
Xiao, Likang
Jiang, Chenyang
Yue, Songkai
Zhang, Meng
zheng, Jia
Liu, Zeming
Dong, Yonghui
author_facet Zhai, Ganggang
Xiao, Likang
Jiang, Chenyang
Yue, Songkai
Zhang, Meng
zheng, Jia
Liu, Zeming
Dong, Yonghui
author_sort Zhai, Ganggang
collection PubMed
description Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the underlying molecular mechanisms of OA could help us to better develop effective therapeutic measures. N6-methyladenosine (m6A) is a methylation that occurs at the adenosine N6-position, which is the most common internal modification on eukaryotic mRNAs. The role and mechanisms of m6A in mammalian gene regulation have been extensively studied. The “Writer”, “eraser”, and “reader” proteins are key proteins involved in the dynamic regulation of m6A modifications. Recent studies on post-transcriptional regulation alone have shown that m6a modification has an important role in the development of OA. This paper summarizes the specific regulatory processes of M6A in disease and reviews the role of m6A in OA, describing its pathophysiological role and molecular mechanisms, as well as its future research trends and potential clinical applications in OA.
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spelling pubmed-92827172022-07-15 Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis Zhai, Ganggang Xiao, Likang Jiang, Chenyang Yue, Songkai Zhang, Meng zheng, Jia Liu, Zeming Dong, Yonghui Front Cell Dev Biol Cell and Developmental Biology Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease. In fact, a deeper understanding of the underlying molecular mechanisms of OA could help us to better develop effective therapeutic measures. N6-methyladenosine (m6A) is a methylation that occurs at the adenosine N6-position, which is the most common internal modification on eukaryotic mRNAs. The role and mechanisms of m6A in mammalian gene regulation have been extensively studied. The “Writer”, “eraser”, and “reader” proteins are key proteins involved in the dynamic regulation of m6A modifications. Recent studies on post-transcriptional regulation alone have shown that m6a modification has an important role in the development of OA. This paper summarizes the specific regulatory processes of M6A in disease and reviews the role of m6A in OA, describing its pathophysiological role and molecular mechanisms, as well as its future research trends and potential clinical applications in OA. Frontiers Media S.A. 2022-06-30 /pmc/articles/PMC9282717/ /pubmed/35846376 http://dx.doi.org/10.3389/fcell.2022.946219 Text en Copyright © 2022 Zhai, Xiao, Jiang, Yue, Zhang, zheng, Liu and Dong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhai, Ganggang
Xiao, Likang
Jiang, Chenyang
Yue, Songkai
Zhang, Meng
zheng, Jia
Liu, Zeming
Dong, Yonghui
Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title_full Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title_fullStr Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title_full_unstemmed Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title_short Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
title_sort regulatory role of n6-methyladenosine (m6a) modification in osteoarthritis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282717/
https://www.ncbi.nlm.nih.gov/pubmed/35846376
http://dx.doi.org/10.3389/fcell.2022.946219
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