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Effects of CYP2C19 variants on the metabolism of tapentadol in vitro
OBJECTIVE(S): This study aims to evaluate the catalytic activities of 31 CYP2C19 alleles and their effects on the metabolism of tapentadol in vitro. MATERIALS AND METHODS: Insect microsomes expressing the CYP2C19 alleles were incubated with 50–1250 μM tapentadol for 40 min at 37 °C and terminated by...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Mashhad University of Medical Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282738/ https://www.ncbi.nlm.nih.gov/pubmed/35911647 http://dx.doi.org/10.22038/IJBMS.2022.56996.12710 |