Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy

Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the neurodegenerative mechanism of tau‐associated pathology remains unclear, molecular elements capable of degrading and/or sequestering neurotoxic tau species...

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Detalles Bibliográficos
Autores principales: Ono, Maiko, Komatsu, Masaaki, Ji, Bin, Takado, Yuhei, Shimojo, Masafumi, Minamihisamatsu, Takeharu, Warabi, Eiji, Yanagawa, Toru, Matsumoto, Gen, Aoki, Ichio, Kanaan, Nicholas M., Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282839/
https://www.ncbi.nlm.nih.gov/pubmed/35662390
http://dx.doi.org/10.1111/acel.13615

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