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Regulation and roles of RNA modifications in aging‐related diseases

With the aging of the global population, accumulating interest is focused on manipulating the fundamental aging‐related signaling pathways to delay the physiological aging process and eventually slow or prevent the appearance or severity of multiple aging‐related diseases. Recently, emerging evidenc...

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Autores principales: Jiapaer, Zeyidan, Su, Dingwen, Hua, Lingyang, Lehmann, Helge Immo, Gokulnath, Priyanka, Vulugundam, Gururaja, Song, Shannan, Zhang, Lingying, Gong, Ye, Li, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282851/
https://www.ncbi.nlm.nih.gov/pubmed/35718942
http://dx.doi.org/10.1111/acel.13657
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author Jiapaer, Zeyidan
Su, Dingwen
Hua, Lingyang
Lehmann, Helge Immo
Gokulnath, Priyanka
Vulugundam, Gururaja
Song, Shannan
Zhang, Lingying
Gong, Ye
Li, Guoping
author_facet Jiapaer, Zeyidan
Su, Dingwen
Hua, Lingyang
Lehmann, Helge Immo
Gokulnath, Priyanka
Vulugundam, Gururaja
Song, Shannan
Zhang, Lingying
Gong, Ye
Li, Guoping
author_sort Jiapaer, Zeyidan
collection PubMed
description With the aging of the global population, accumulating interest is focused on manipulating the fundamental aging‐related signaling pathways to delay the physiological aging process and eventually slow or prevent the appearance or severity of multiple aging‐related diseases. Recently, emerging evidence has shown that RNA modifications, which were historically considered infrastructural features of cellular RNAs, are dynamically regulated across most of the RNA species in cells and thereby critically involved in major biological processes, including cellular senescence and aging. In this review, we summarize the current knowledge about RNA modifications and provide a catalog of RNA modifications on different RNA species, including mRNAs, miRNAs, lncRNA, tRNAs, and rRNAs. Most importantly, we focus on the regulation and roles of these RNA modifications in aging‐related diseases, including neurodegenerative diseases, cardiovascular diseases, cataracts, osteoporosis, and fertility decline. This would be an important step toward a better understanding of fundamental aging mechanisms and thereby facilitating the development of novel diagnostics and therapeutics for aging‐related diseases.
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spelling pubmed-92828512022-07-15 Regulation and roles of RNA modifications in aging‐related diseases Jiapaer, Zeyidan Su, Dingwen Hua, Lingyang Lehmann, Helge Immo Gokulnath, Priyanka Vulugundam, Gururaja Song, Shannan Zhang, Lingying Gong, Ye Li, Guoping Aging Cell Review Article With the aging of the global population, accumulating interest is focused on manipulating the fundamental aging‐related signaling pathways to delay the physiological aging process and eventually slow or prevent the appearance or severity of multiple aging‐related diseases. Recently, emerging evidence has shown that RNA modifications, which were historically considered infrastructural features of cellular RNAs, are dynamically regulated across most of the RNA species in cells and thereby critically involved in major biological processes, including cellular senescence and aging. In this review, we summarize the current knowledge about RNA modifications and provide a catalog of RNA modifications on different RNA species, including mRNAs, miRNAs, lncRNA, tRNAs, and rRNAs. Most importantly, we focus on the regulation and roles of these RNA modifications in aging‐related diseases, including neurodegenerative diseases, cardiovascular diseases, cataracts, osteoporosis, and fertility decline. This would be an important step toward a better understanding of fundamental aging mechanisms and thereby facilitating the development of novel diagnostics and therapeutics for aging‐related diseases. John Wiley and Sons Inc. 2022-06-19 2022-07 /pmc/articles/PMC9282851/ /pubmed/35718942 http://dx.doi.org/10.1111/acel.13657 Text en © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jiapaer, Zeyidan
Su, Dingwen
Hua, Lingyang
Lehmann, Helge Immo
Gokulnath, Priyanka
Vulugundam, Gururaja
Song, Shannan
Zhang, Lingying
Gong, Ye
Li, Guoping
Regulation and roles of RNA modifications in aging‐related diseases
title Regulation and roles of RNA modifications in aging‐related diseases
title_full Regulation and roles of RNA modifications in aging‐related diseases
title_fullStr Regulation and roles of RNA modifications in aging‐related diseases
title_full_unstemmed Regulation and roles of RNA modifications in aging‐related diseases
title_short Regulation and roles of RNA modifications in aging‐related diseases
title_sort regulation and roles of rna modifications in aging‐related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282851/
https://www.ncbi.nlm.nih.gov/pubmed/35718942
http://dx.doi.org/10.1111/acel.13657
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