Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration

Autophagy is characterized as a cytoprotective process and inhibition of autophagy with medicinally active agents, such as chloroquine (CQ) is proposed as a prospective adjuvant therapy for cancer. Here, we examined the preclinical effects of CQ combined with the MEK inhibitor trametinib (TRA) on me...

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Detalles Bibliográficos
Autores principales: Degan, Simone, May, Brian L., Jin, Yingai J., Hammoda, Manel Ben, Sun, Huiying, Zhang, Guoqiang, Wang, Yan, Erdmann, Detlev, Warren, Warren, Zhang, Jennifer Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282877/
https://www.ncbi.nlm.nih.gov/pubmed/35847840
http://dx.doi.org/10.3389/fonc.2022.782877

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