KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer

Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRAS(G12D) mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination. However, the regulatory mechanism underlying KRAS(G12D) mutat...

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Detalles Bibliográficos
Autores principales: Luo, Yuming, Li, Zhihua, Kong, Yao, He, Wang, Zheng, Hanhao, An, Mingjie, Lin, Yan, Zhang, Dingwen, Yang, Jiabin, Zhao, Yue, Chen, Changhao, Chen, Rufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282935/
https://www.ncbi.nlm.nih.gov/pubmed/35579947
http://dx.doi.org/10.1172/JCI157644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282935/
https://www.ncbi.nlm.nih.gov/pubmed/35579947
http://dx.doi.org/10.1172/JCI157644

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