Cargando…
KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRAS(G12D) mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination. However, the regulatory mechanism underlying KRAS(G12D) mutat...
Autores principales: | Luo, Yuming, Li, Zhihua, Kong, Yao, He, Wang, Zheng, Hanhao, An, Mingjie, Lin, Yan, Zhang, Dingwen, Yang, Jiabin, Zhao, Yue, Chen, Changhao, Chen, Rufu |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282935/ https://www.ncbi.nlm.nih.gov/pubmed/35579947 http://dx.doi.org/10.1172/JCI157644 |
Ejemplares similares
-
Extracellular vesicle-mediated heterogeneous communication between cancer and the lymphatic system facilitates lymphatic metastasis
por: Chen, Changhao, et al.
Publicado: (2023) -
Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
por: Kong, Yao, et al.
Publicado: (2023) -
SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer
por: Diao, Xiayao, et al.
Publicado: (2023) -
circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer
por: Kong, Yao, et al.
Publicado: (2020) -
KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer
por: Pirlog, Radu, et al.
Publicado: (2022)