Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis

Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation. We found that FoxO1 links overnutrition to hepatic inflammation by regulating macrophage polarization and activation....

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Detalles Bibliográficos
Autores principales: Lee, Sojin, Usman, Taofeek O., Yamauchi, Jun, Chhetri, Goma, Wang, Xingchun, Coudriet, Gina M., Zhu, Cuiling, Gao, Jingyang, McConnell, Riley, Krantz, Kyler, Rajasundaram, Dhivyaa, Singh, Sucha, Piganelli, Jon, Ostrowska, Alina, Soto-Gutierrez, Alejandro, Monga, Satdarshan P., Singhi, Aatur D., Muzumdar, Radhika, Tsung, Allan, Dong, H. Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282937/
https://www.ncbi.nlm.nih.gov/pubmed/35700043
http://dx.doi.org/10.1172/JCI154333

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