Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and...

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Autores principales: Gao, Mengjia, Xin, Jingxin, Li, Xiaoling, Gao, Ling, Shao, Shanshan, Zhao, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282983/
https://www.ncbi.nlm.nih.gov/pubmed/35844837
http://dx.doi.org/10.1155/2022/3200932
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author Gao, Mengjia
Xin, Jingxin
Li, Xiaoling
Gao, Ling
Shao, Shanshan
Zhao, Meng
author_facet Gao, Mengjia
Xin, Jingxin
Li, Xiaoling
Gao, Ling
Shao, Shanshan
Zhao, Meng
author_sort Gao, Mengjia
collection PubMed
description Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH.
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spelling pubmed-92829832022-07-15 Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis Gao, Mengjia Xin, Jingxin Li, Xiaoling Gao, Ling Shao, Shanshan Zhao, Meng Gastroenterol Res Pract Research Article Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH. Hindawi 2022-07-07 /pmc/articles/PMC9282983/ /pubmed/35844837 http://dx.doi.org/10.1155/2022/3200932 Text en Copyright © 2022 Mengjia Gao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gao, Mengjia
Xin, Jingxin
Li, Xiaoling
Gao, Ling
Shao, Shanshan
Zhao, Meng
Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title_full Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title_fullStr Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title_full_unstemmed Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title_short Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis
title_sort differential expression profiles of mrna and noncoding rna and analysis of competitive endogenous rna regulatory networks in nonalcoholic steatohepatitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282983/
https://www.ncbi.nlm.nih.gov/pubmed/35844837
http://dx.doi.org/10.1155/2022/3200932
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