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Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the cl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283057/ https://www.ncbi.nlm.nih.gov/pubmed/35845949 http://dx.doi.org/10.1155/2022/8118909 |
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author | Shi, Shuai Ma, Hong-Yan Sang, Yin-zhou Ju, Ying-Bo Liu, Xiao-Yun Zhang, Zhi-Gang |
author_facet | Shi, Shuai Ma, Hong-Yan Sang, Yin-zhou Ju, Ying-Bo Liu, Xiao-Yun Zhang, Zhi-Gang |
author_sort | Shi, Shuai |
collection | PubMed |
description | The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the clinical pathological data of patients. We selected 89 cases of triple-negative breast cancer and 62 cases of normal breast tissue specimens. Immunohistochemical methods were used to detect the expression levels of CMTM6 and PD-L1 and to carefully study differences in their expression. The expression of CMTM6 and PD-L1 in TNBC was higher than that in normal breast tissue, and the expression of the two was positively correlated (p < 0.05). In TNBC, CMTM6 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, and TNM stage (p < 0.05). PD-L1 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, TNM stage, and vascular infiltration (p < 0.05). Kaplan-Meier analysis showed that the positive expression of CMTM6 and PD-L1 had no correlation with the survival rate of patients (p > 0.05). According to KM-plotter, we found that a higher CMTM6 expression was positively related with relapse-free survival rate of patients (p < 0.05). A higher PD-L1 expression was positively correlated with relapse-free, overall, and distant metastasis survival rate of patients (p < 0.05). In timer database, we found a positive correlation between the expression of CMTM6 and PD-L1 in triple-negative breast cancer. Both CMTM6 and PD-L1 are highly expressed in TNBC, and their expressions are positively related. In the future, the two gene might become targets for the treatment of TNBC, providing a basis of clinical treatment of TNBC. |
format | Online Article Text |
id | pubmed-9283057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92830572022-07-15 Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer Shi, Shuai Ma, Hong-Yan Sang, Yin-zhou Ju, Ying-Bo Liu, Xiao-Yun Zhang, Zhi-Gang Biomed Res Int Research Article The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the clinical pathological data of patients. We selected 89 cases of triple-negative breast cancer and 62 cases of normal breast tissue specimens. Immunohistochemical methods were used to detect the expression levels of CMTM6 and PD-L1 and to carefully study differences in their expression. The expression of CMTM6 and PD-L1 in TNBC was higher than that in normal breast tissue, and the expression of the two was positively correlated (p < 0.05). In TNBC, CMTM6 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, and TNM stage (p < 0.05). PD-L1 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, TNM stage, and vascular infiltration (p < 0.05). Kaplan-Meier analysis showed that the positive expression of CMTM6 and PD-L1 had no correlation with the survival rate of patients (p > 0.05). According to KM-plotter, we found that a higher CMTM6 expression was positively related with relapse-free survival rate of patients (p < 0.05). A higher PD-L1 expression was positively correlated with relapse-free, overall, and distant metastasis survival rate of patients (p < 0.05). In timer database, we found a positive correlation between the expression of CMTM6 and PD-L1 in triple-negative breast cancer. Both CMTM6 and PD-L1 are highly expressed in TNBC, and their expressions are positively related. In the future, the two gene might become targets for the treatment of TNBC, providing a basis of clinical treatment of TNBC. Hindawi 2022-07-07 /pmc/articles/PMC9283057/ /pubmed/35845949 http://dx.doi.org/10.1155/2022/8118909 Text en Copyright © 2022 Shuai Shi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shi, Shuai Ma, Hong-Yan Sang, Yin-zhou Ju, Ying-Bo Liu, Xiao-Yun Zhang, Zhi-Gang Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title | Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title_full | Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title_fullStr | Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title_full_unstemmed | Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title_short | Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer |
title_sort | expression and clinical significance of cmtm6 and pd-l1 in triple-negative breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283057/ https://www.ncbi.nlm.nih.gov/pubmed/35845949 http://dx.doi.org/10.1155/2022/8118909 |
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