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Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer

The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the cl...

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Autores principales: Shi, Shuai, Ma, Hong-Yan, Sang, Yin-zhou, Ju, Ying-Bo, Liu, Xiao-Yun, Zhang, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283057/
https://www.ncbi.nlm.nih.gov/pubmed/35845949
http://dx.doi.org/10.1155/2022/8118909
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author Shi, Shuai
Ma, Hong-Yan
Sang, Yin-zhou
Ju, Ying-Bo
Liu, Xiao-Yun
Zhang, Zhi-Gang
author_facet Shi, Shuai
Ma, Hong-Yan
Sang, Yin-zhou
Ju, Ying-Bo
Liu, Xiao-Yun
Zhang, Zhi-Gang
author_sort Shi, Shuai
collection PubMed
description The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the clinical pathological data of patients. We selected 89 cases of triple-negative breast cancer and 62 cases of normal breast tissue specimens. Immunohistochemical methods were used to detect the expression levels of CMTM6 and PD-L1 and to carefully study differences in their expression. The expression of CMTM6 and PD-L1 in TNBC was higher than that in normal breast tissue, and the expression of the two was positively correlated (p < 0.05). In TNBC, CMTM6 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, and TNM stage (p < 0.05). PD-L1 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, TNM stage, and vascular infiltration (p < 0.05). Kaplan-Meier analysis showed that the positive expression of CMTM6 and PD-L1 had no correlation with the survival rate of patients (p > 0.05). According to KM-plotter, we found that a higher CMTM6 expression was positively related with relapse-free survival rate of patients (p < 0.05). A higher PD-L1 expression was positively correlated with relapse-free, overall, and distant metastasis survival rate of patients (p < 0.05). In timer database, we found a positive correlation between the expression of CMTM6 and PD-L1 in triple-negative breast cancer. Both CMTM6 and PD-L1 are highly expressed in TNBC, and their expressions are positively related. In the future, the two gene might become targets for the treatment of TNBC, providing a basis of clinical treatment of TNBC.
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spelling pubmed-92830572022-07-15 Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer Shi, Shuai Ma, Hong-Yan Sang, Yin-zhou Ju, Ying-Bo Liu, Xiao-Yun Zhang, Zhi-Gang Biomed Res Int Research Article The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in triple-negative breast cancer and their correlation with the clinical pathological data of patients. We selected 89 cases of triple-negative breast cancer and 62 cases of normal breast tissue specimens. Immunohistochemical methods were used to detect the expression levels of CMTM6 and PD-L1 and to carefully study differences in their expression. The expression of CMTM6 and PD-L1 in TNBC was higher than that in normal breast tissue, and the expression of the two was positively correlated (p < 0.05). In TNBC, CMTM6 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, and TNM stage (p < 0.05). PD-L1 expression is positively correlated with tumor size, lymph node metastasis, Ki67 proliferation index, TNM stage, and vascular infiltration (p < 0.05). Kaplan-Meier analysis showed that the positive expression of CMTM6 and PD-L1 had no correlation with the survival rate of patients (p > 0.05). According to KM-plotter, we found that a higher CMTM6 expression was positively related with relapse-free survival rate of patients (p < 0.05). A higher PD-L1 expression was positively correlated with relapse-free, overall, and distant metastasis survival rate of patients (p < 0.05). In timer database, we found a positive correlation between the expression of CMTM6 and PD-L1 in triple-negative breast cancer. Both CMTM6 and PD-L1 are highly expressed in TNBC, and their expressions are positively related. In the future, the two gene might become targets for the treatment of TNBC, providing a basis of clinical treatment of TNBC. Hindawi 2022-07-07 /pmc/articles/PMC9283057/ /pubmed/35845949 http://dx.doi.org/10.1155/2022/8118909 Text en Copyright © 2022 Shuai Shi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shi, Shuai
Ma, Hong-Yan
Sang, Yin-zhou
Ju, Ying-Bo
Liu, Xiao-Yun
Zhang, Zhi-Gang
Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title_full Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title_fullStr Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title_full_unstemmed Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title_short Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer
title_sort expression and clinical significance of cmtm6 and pd-l1 in triple-negative breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283057/
https://www.ncbi.nlm.nih.gov/pubmed/35845949
http://dx.doi.org/10.1155/2022/8118909
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