Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

Protein posttranslational modification regulates several biological mechanisms, including tumor progression. In this study, we show that the mitochondrial Sirtuin 4 (SIRT4), which has ADP-ribosylation activity, plays a role in prostate cancer (PCa) progression. Firstly, SIRT4 expression was verified...

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Detalles Bibliográficos
Autores principales: Mao, Liang, Hong, Xi, Xu, Luwei, Wang, Xinning, Liu, Jingyu, Wang, Hao, Qian, Yiguan, Zhao, Jun, Jia, Ruipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283077/
https://www.ncbi.nlm.nih.gov/pubmed/35847357
http://dx.doi.org/10.1155/2022/5498743

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