Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range

PURPOSE: Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising endogenous CYP3A4 biomarker, additional investigations are required to evaluate its...

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Detalles Bibliográficos
Autores principales: Eide Kvitne, Kine, Hole, Kristine, Krogstad, Veronica, Wollmann, Birgit Malene, Wegler, Christine, Johnson, Line K., Hertel, Jens K., Artursson, Per, Karlsson, Cecilia, Andersson, Shalini, Andersson, Tommy B., Sandbu, Rune, Hjelmesæth, Jøran, Skovlund, Eva, Christensen, Hege, Jansson-Löfmark, Rasmus, Åsberg, Anders, Molden, Espen, Robertsen, Ida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283167/
https://www.ncbi.nlm.nih.gov/pubmed/35648149
http://dx.doi.org/10.1007/s00228-022-03336-9

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