Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1

The multifaceted nature of senescent cell cycle arrest necessitates the targeting of multiple factors arresting or promoting the cell cycle. We report that co-inhibition of ATM and ROCK by KU-60019 and Y-27632, respectively, synergistically increases the proliferation of human diploid fibroblasts un...

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Detalles Bibliográficos
Autores principales: Yang, Eun Jae, Park, Ji Hwan, Cho, Hyun-Ji, Hwang, Jeong-A, Woo, Seung-Hwa, Park, Chi Hyun, Kim, Sung Young, Park, Joon Tae, Park, Sang Chul, Hwang, Daehee, Lee, Young-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283421/
https://www.ncbi.nlm.nih.gov/pubmed/35835838
http://dx.doi.org/10.1038/s42003-022-03658-5

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