Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma

BACKGROUND: Medulloblastoma is the most frequent brain malignancy of childhood. The current multimodal treatment comes at the expense of serious and often long-lasting side effects. Drug repurposing is a strategy to fast-track anti-cancer therapy with low toxicity. Here, we showed the ability of β-b...

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Detalles Bibliográficos
Autores principales: Rossi, Maïlys, Talbot, Julie, Piris, Patricia, Grand, Marion Le, Montero, Marie-Pierre, Matteudi, Mélanie, Agavnian-Couquiaud, Emilie, Appay, Romain, Keime, Céline, Williamson, Daniel, Buric, Duje, Bourgarel, Véronique, Padovani, Laetitia, Clifford, Steven C., Ayrault, Olivier, Pasquier, Eddy, André, Nicolas, Carré, Manon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283511/
https://www.ncbi.nlm.nih.gov/pubmed/35816899
http://dx.doi.org/10.1016/j.ebiom.2022.104149

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