Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine’s metabolic fate in vivo. Dietary (13)C(6) labeled lysine was tracked to lysine met...

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Detalles Bibliográficos
Autores principales: Rinschen, Markus M., Palygin, Oleg, El-Meanawy, Ashraf, Domingo-Almenara, Xavier, Palermo, Amelia, Dissanayake, Lashodya V., Golosova, Daria, Schafroth, Michael A., Guijas, Carlos, Demir, Fatih, Jaegers, Johannes, Gliozzi, Megan L., Xue, Jingchuan, Hoehne, Martin, Benzing, Thomas, Kok, Bernard P., Saez, Enrique, Bleich, Markus, Himmerkus, Nina, Weisz, Ora A., Cravatt, Benjamin F., Krüger, Marcus, Benton, H. Paul, Siuzdak, Gary, Staruschenko, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283537/
https://www.ncbi.nlm.nih.gov/pubmed/35835746
http://dx.doi.org/10.1038/s41467-022-31670-0

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